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This abnormal pattern of neuron positioning in the cerebral cortex is reminiscent of that observed in mouse mutants defective in the reelin-signaling pathway. Significantly, the level of reelin in the neocortex is much reduced when II\u03b2 is absent. These results implicate a role of II\u03b2 in brain development. The enzyme may be required in implementing particular genetic programs in postmitotic cells, such as reelin expression in Cajal-Retzius cells, perhaps through its action on nucleoprotein structure of particular chromosomal regions.<\/jats:p>","DOI":"10.1073\/pnas.1232376100","type":"journal-article","created":{"date-parts":[[2003,6,10]],"date-time":"2003-06-10T17:06:36Z","timestamp":1055264796000},"page":"7123-7128","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":101,"title":["Aberrant lamination in the cerebral cortex of mouse embryos lacking DNA topoisomerase II\u03b2"],"prefix":"10.1073","volume":"100","author":[{"given":"Yi Lisa","family":"Lyu","sequence":"first","affiliation":[{"name":"Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138"}]},{"given":"James C.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138"}]}],"member":"341","published-online":{"date-parts":[[2003,5,28]]},"reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.65.070196.003223"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm831"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.70.1.369"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.9.2616"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(85)80028-3"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(87)90518-6"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-1878(199803)20:3<215::AID-BIES5>3.0.CO;2-Q"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5450.131"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9861(20010305)431:2<228::AID-CNE1067>3.0.CO;2-M"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M008517200"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.14.5166"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.13.12.1524"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/75973"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(96)00035-2"},{"key":"e_1_3_2_15_2","unstructured":"Hogan B. 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