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Here we have demonstrated that a recombinant CMV vector expressing RAE-1\u03b3, a cellular ligand for activating NKG2D receptor expressed on several types of immune cells, has tremendous potential for subverting viral immunoevasion and enhancing the efficiency of the CD8 T-cell response against vectored antigens. This study demonstrates a significant new approach in designing T-cell\u2013based vaccine vectors.<\/jats:p>","DOI":"10.1073\/pnas.1310215110","type":"journal-article","created":{"date-parts":[[2013,9,20]],"date-time":"2013-09-20T05:59:00Z","timestamp":1379656740000},"page":"16550-16555","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":27,"title":["Superior induction and maintenance of protective CD8 T cells in mice infected with mouse cytomegalovirus vector expressing RAE-1\u03b3"],"prefix":"10.1073","volume":"110","author":[{"given":"Tihana","family":"Tr\u0161an","sequence":"first","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia;"}]},{"given":"Andreas","family":"Busche","sequence":"additional","affiliation":[{"name":"Department of Virology, Hannover Medical School, 30625 Hannover, Germany;"}]},{"given":"Maja","family":"Abram","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Parasitology, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia;"}]},{"given":"Felix M.","family":"Wensveen","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia;"}]},{"given":"Niels A.","family":"Lemmermann","sequence":"additional","affiliation":[{"name":"Institute for Virology, University Medical Center of the Johannes Gutenberg-University Mainz, 55131 Mainz, Germany;"}]},{"given":"Maja","family":"Arapovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia;"}]},{"given":"Marina","family":"Babi\u0107","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia;"}]},{"given":"Adriana","family":"Tomi\u0107","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia;"}]},{"given":"Mijo","family":"Golemac","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia;"}]},{"given":"Melanie M.","family":"Brinkmann","sequence":"additional","affiliation":[{"name":"Viral Immune Modulation Group, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany; and"}]},{"given":"Wiebke","family":"J\u00e4ger","sequence":"additional","affiliation":[{"name":"Department of Virology, Hannover Medical School, 30625 Hannover, Germany;"}]},{"given":"Annette","family":"Oxenius","sequence":"additional","affiliation":[{"name":"Institute of Microbiology, ETH Z\u00fcrich, 8093 Zurich, Switzerland"}]},{"given":"Bojan","family":"Poli\u0107","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia;"}]},{"given":"Astrid","family":"Krmpoti\u0107","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia;"}]},{"given":"Martin","family":"Messerle","sequence":"additional","affiliation":[{"name":"Department of Virology, Hannover Medical School, 30625 Hannover, Germany;"}]},{"given":"Stipan","family":"Jonji\u0107","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine, University of Rijeka, 51000 Rijeka, 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