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Here we compare the folding mechanisms of an Ising-like model that quantitatively explains a wide range of experimental data with fully atomistic simulations from the Shaw group. Not only are the simplifying assumptions of the theoretical model consistent with the simulations, but the folding mechanisms are remarkably similar. One of the key assumptions, that the 3D structure of the folded protein determines folding mechanisms, is strongly supported by the analysis in the accompanying paper by Best et al. 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