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Here, we combine machine learning with structure-based protein design to identify and redesign T-cell epitopes without disrupting function of the target protein. We test the method experimentally, removing T-cell epitopes from GFP and\n                    <jats:italic>Pseudomonas<\/jats:italic>\n                    exotoxin A while maintaining function.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1321126111","type":"journal-article","created":{"date-parts":[[2014,5,19]],"date-time":"2014-05-19T22:36:03Z","timestamp":1400538963000},"page":"8577-8582","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":121,"title":["Removing T-cell epitopes with computational protein design"],"prefix":"10.1073","volume":"111","author":[{"given":"Chris","family":"King","sequence":"first","affiliation":[{"name":"Institute for Protein Design, Department of Biochemistry and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esteban N.","family":"Garza","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Washington, Seattle, WA 98195; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronit","family":"Mazor","sequence":"additional","affiliation":[{"name":"National Cancer Institute and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan L.","family":"Linehan","sequence":"additional","affiliation":[{"name":"National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ira","family":"Pastan","sequence":"additional","affiliation":[{"name":"National Cancer Institute and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Pepper","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Washington, Seattle, WA 98195; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Baker","sequence":"additional","affiliation":[{"name":"Institute for Protein Design, Department of Biochemistry and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2014,5,19]]},"reference":[{"key":"e_1_3_3_1_2","first-page":"405","volume-title":"Naive and Memory B Cells in T-Cell-Dependent and T-Independent Responses. 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