{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T21:20:39Z","timestamp":1773955239466,"version":"3.50.1"},"reference-count":57,"publisher":"Proceedings of the National Academy of Sciences","issue":"29","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2014,7,22]]},"abstract":"<jats:title>Significance<\/jats:title>\n          <jats:p>\u03b1-Synuclein (\u03b1S) inclusions are a hallmark of many progressive neurodegenerative disorders. Previously, intracerebral injection of exogenous preformed fibrillar \u03b1S in mouse models was shown to induce neuronal \u03b1S aggregation\u2014a finding that has been interpreted as a prion-like mechanism. We now show that \u03b1S inclusion pathology can be induced in the brain and spinal cord of \u03b1S transgenic mice by a single peripheral intramuscular injection of \u03b1S. The formation of \u03b1S inclusions occurred concurrently with the presentation of a motor impairment in mice expressing mutant Ala53Thr human \u03b1S. This new model of robust and predictable induction of \u03b1S pathology will be especially valuable to further study the pathogenic mechanisms and assessment of therapeutic interventions.<\/jats:p>","DOI":"10.1073\/pnas.1321785111","type":"journal-article","created":{"date-parts":[[2014,7,8]],"date-time":"2014-07-08T03:01:33Z","timestamp":1404788493000},"page":"10732-10737","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":299,"title":["Intramuscular injection of \u03b1-synuclein induces CNS \u03b1-synuclein pathology and a rapid-onset motor phenotype in transgenic mice"],"prefix":"10.1073","volume":"111","author":[{"given":"Amanda N.","family":"Sacino","sequence":"first","affiliation":[{"name":"Department of Neuroscience,"},{"name":"Center for Translational Research in Neurodegenerative Disease, and"}]},{"given":"Mieu","family":"Brooks","sequence":"additional","affiliation":[{"name":"Department of Neuroscience,"},{"name":"Center 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