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Surprisingly, 2C TCR<jats:sup>+<\/jats:sup>CD8<jats:sup>+<\/jats:sup>single-positive T cells emerge in massive numbers in fetal thymic organ culture originating from 2C transgenic, H-2K<jats:sup>b<\/jats:sup>D<jats:sup>b\u2212\/\u2212<\/jats:sup>(2C<jats:sup>+<\/jats:sup>K<jats:sup>b<\/jats:sup>D<jats:sup>b\u2212\/\u2212<\/jats:sup>) but not in fetal thymic organ culture from \u03b2<jats:sub>2<\/jats:sub>-microglobulin<jats:sup>\u2212\/\u2212<\/jats:sup>2C transgenic animals. Mature CD8<jats:sup>+<\/jats:sup>T cells are observed in newborn but not in adult 2C<jats:sup>+<\/jats:sup>K<jats:sup>b<\/jats:sup>D<jats:sup>b\u2212\/\u2212<\/jats:sup>mice. These CD8<jats:sup>+<\/jats:sup>T cells express the \u03b1<jats:sub>4<\/jats:sub>\u03b2<jats:sub>7<\/jats:sub>integrin, which allows them to populate the intestine, a pattern of migration visualized by intrathymic injection of FITC and subsequent accrual of FITC-labeled lymphocytes in the gut. We conclude that the 2C TCR is reactive not only with H-2L<jats:sup>d<\/jats:sup>and H-2K<jats:sup>b<\/jats:sup>, but also with nonclassical MHC class I products to enable positive selection of 2C<jats:sup>+<\/jats:sup>T cells in the fetal and newborn thymus and to support their maintenance in the intestine.<\/jats:p>","DOI":"10.1073\/pnas.141143298","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T14:45:09Z","timestamp":1027694709000},"page":"7437-7442","update-policy":"http:\/\/dx.doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":31,"title":["Positive selection of an MHC class-I restricted TCR in the absence of classical MHC class I molecules"],"prefix":"10.1073","volume":"98","author":[{"given":"Madelon M.","family":"Maurice","sequence":"first","affiliation":[{"name":"Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115"}]},{"given":"Dina 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