{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T18:02:46Z","timestamp":1776448966385,"version":"3.51.2"},"reference-count":40,"publisher":"Proceedings of the National Academy of Sciences","issue":"14","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2001,7,3]]},"abstract":"<jats:p>\n            Rearrangements of the high mobility group protein I-C (HMGI-C) gene, consisting in the loss of the carboxyl-terminal tail, have been frequently detected in benign human tumors of mesenchymal origin. We have previously demonstrated that transgenic (TG) mice carrying a truncated HMGI-C construct (HMGI-C\/T) exhibit a giant phenotype together with a predominantly abdominal\/pelvic lipomatosis. Here, we report that HMGI-C\/T TG mice develop natural killer (NK)-T\/NK cell lymphomas starting from 12 months of age. We found an increased expression of IL-2 and IL-15 proteins and their receptors in these lymphomas, and we demonstrate that HMGI-C\/T protein positively regulates their expression\n            <jats:italic>in vitro<\/jats:italic>\n            . Therefore, the HMGI-C\/T-mediated chronic stimulation of the IL-2\/IL-15 pathway could be responsible for the onset of NK-T\/NK cell lymphomas in HMGI-C\/T TG mice.\n          <\/jats:p>","DOI":"10.1073\/pnas.141224998","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T14:34:10Z","timestamp":1027694050000},"page":"7970-7975","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":81,"title":["Onset of natural killer cell lymphomas in transgenic mice carrying a truncated HMGI-C gene by the chronic stimulation of the IL-2 and IL-15 pathway"],"prefix":"10.1073","volume":"98","author":[{"given":"Gustavo","family":"Baldassarre","sequence":"first","affiliation":[{"name":"Kimmel Cancer Center, Jefferson Medical College, Philadelphia, PA 19107; Dipartimento di Biologia e Patologia Cellulare e Molecolare, Centro di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Facolt\u00e0 di Medicina e Chirurgia, Universit\u00e0 degli Studi di Napoli \u201cFederico II,\u201d 80131 Naples, Italy; Experimental Histopathology, Fox-Chase Cancer Center, Philadelphia, PA 19111; Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of..."}]},{"given":"Monica","family":"Fedele","sequence":"additional","affiliation":[{"name":"Kimmel Cancer Center, Jefferson Medical College, Philadelphia, PA 19107; Dipartimento di Biologia e Patologia Cellulare e Molecolare, Centro di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Facolt\u00e0 di Medicina e Chirurgia, Universit\u00e0 degli Studi di Napoli \u201cFederico II,\u201d 80131 Naples, Italy; Experimental Histopathology, Fox-Chase Cancer Center, Philadelphia, PA 19111; Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of..."}]},{"given":"Sabrina","family":"Battista","sequence":"additional","affiliation":[{"name":"Kimmel Cancer Center, Jefferson Medical College, Philadelphia, PA 19107; Dipartimento di Biologia e Patologia Cellulare e Molecolare, Centro di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Facolt\u00e0 di Medicina e Chirurgia, Universit\u00e0 degli Studi di Napoli \u201cFederico II,\u201d 80131 Naples, Italy; Experimental Histopathology, Fox-Chase Cancer Center, Philadelphia, PA 19111; Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of..."}]},{"given":"Andrea","family":"Vecchione","sequence":"additional","affiliation":[{"name":"Kimmel Cancer Center, Jefferson Medical College, Philadelphia, PA 19107; Dipartimento di Biologia e Patologia Cellulare e Molecolare, Centro di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Facolt\u00e0 di Medicina e Chirurgia, Universit\u00e0 degli Studi di Napoli \u201cFederico II,\u201d 80131 Naples, Italy; Experimental Histopathology, Fox-Chase Cancer Center, Philadelphia, PA 19111; Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of..."}]},{"given":"Andres J. P.","family":"Klein-Szanto","sequence":"additional","affiliation":[{"name":"Kimmel Cancer Center, Jefferson Medical College, Philadelphia, PA 19107; Dipartimento di Biologia e Patologia Cellulare e Molecolare, Centro di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Facolt\u00e0 di Medicina e Chirurgia, Universit\u00e0 degli Studi di Napoli \u201cFederico II,\u201d 80131 Naples, Italy; Experimental Histopathology, Fox-Chase Cancer Center, Philadelphia, PA 19111; Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of..."}]},{"given":"Massimo","family":"Santoro","sequence":"additional","affiliation":[{"name":"Kimmel Cancer Center, Jefferson Medical College, Philadelphia, PA 19107; Dipartimento di Biologia e Patologia Cellulare e Molecolare, Centro di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Facolt\u00e0 di Medicina e Chirurgia, Universit\u00e0 degli Studi di Napoli \u201cFederico II,\u201d 80131 Naples, Italy; Experimental Histopathology, Fox-Chase Cancer Center, Philadelphia, PA 19111; Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of..."}]},{"given":"Thomas A.","family":"Waldmann","sequence":"additional","affiliation":[{"name":"Kimmel Cancer Center, Jefferson Medical College, Philadelphia, PA 19107; Dipartimento di Biologia e Patologia Cellulare e Molecolare, Centro di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Facolt\u00e0 di Medicina e Chirurgia, Universit\u00e0 degli Studi di Napoli \u201cFederico II,\u201d 80131 Naples, Italy; Experimental Histopathology, Fox-Chase Cancer Center, Philadelphia, PA 19111; Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of..."}]},{"given":"Nazli","family":"Azimi","sequence":"additional","affiliation":[{"name":"Kimmel Cancer Center, Jefferson Medical College, Philadelphia, PA 19107; Dipartimento di Biologia e Patologia Cellulare e Molecolare, Centro di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Facolt\u00e0 di Medicina e Chirurgia, Universit\u00e0 degli Studi di Napoli \u201cFederico II,\u201d 80131 Naples, Italy; Experimental Histopathology, Fox-Chase Cancer Center, Philadelphia, PA 19111; Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of..."}]},{"given":"Carlo M.","family":"Croce","sequence":"additional","affiliation":[{"name":"Kimmel Cancer Center, Jefferson Medical College, Philadelphia, PA 19107; Dipartimento di Biologia e Patologia Cellulare e Molecolare, Centro di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Facolt\u00e0 di Medicina e Chirurgia, Universit\u00e0 degli Studi di Napoli \u201cFederico II,\u201d 80131 Naples, Italy; Experimental Histopathology, Fox-Chase Cancer Center, Philadelphia, PA 19111; Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of..."}]},{"given":"Alfredo","family":"Fusco","sequence":"additional","affiliation":[{"name":"Kimmel Cancer Center, Jefferson Medical College, Philadelphia, PA 19107; Dipartimento di Biologia e Patologia Cellulare e Molecolare, Centro di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Facolt\u00e0 di Medicina e Chirurgia, Universit\u00e0 degli Studi di Napoli \u201cFederico II,\u201d 80131 Naples, Italy; Experimental Histopathology, Fox-Chase Cancer Center, Philadelphia, PA 19111; Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of..."}]}],"member":"341","published-online":{"date-parts":[[2001,6,26]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/19.24.6793"},{"key":"e_1_3_3_2_2","first-page":"187","volume-title":"Architecture of Eukaryotic Genes","author":"Goodwin G","year":"1988","unstructured":"G Goodwin, 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