{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:25:38Z","timestamp":1781105138554,"version":"3.54.1"},"reference-count":29,"publisher":"National Academy of Sciences","issue":"16","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2001,7,31]]},"abstract":"<jats:p>What determines the firing rate of cortical neurons in the absence of external sensory input or motor behavior, such as during sleep? Here we report that, in a familiar environment, the discharge frequency of simultaneously recorded individual CA1 pyramidal neurons and the coactivation of cell pairs remain highly correlated across sleep\u2013wake\u2013sleep sequences. However, both measures were affected when new sets of neurons were activated in a novel environment. Nevertheless, the grand mean firing rate of the whole pyramidal cell population remained constant across behavioral states and testing conditions. The findings suggest that long-term firing patterns of single cells can be modified by experience. We hypothesize that increased firing rates of recently used neurons are associated with a concomitant decrease in the discharge activity of the remaining population, leaving the mean excitability of the hippocampal network unaltered.<\/jats:p>","DOI":"10.1073\/pnas.161274398","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:34:10Z","timestamp":1027679650000},"page":"9386-9390","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":125,"title":["Firing rates of hippocampal neurons are preserved during subsequent sleep episodes and modified by novel awake experience"],"prefix":"10.1073","volume":"98","author":[{"given":"Hajime","family":"Hirase","sequence":"first","affiliation":[{"name":"Center for Molecular and Behavioral Neuroscience, Rutgers, State University of New Jersey, 197 University Avenue, Newark, NJ 07102"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Leinekugel","sequence":"additional","affiliation":[{"name":"Center for Molecular and Behavioral Neuroscience, Rutgers, State University of New Jersey, 197 University Avenue, Newark, NJ 07102"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e1s","family":"Czurk\u00f3","sequence":"additional","affiliation":[{"name":"Center for Molecular and Behavioral Neuroscience, Rutgers, State University of New Jersey, 197 University Avenue, Newark, NJ 07102"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jozsef","family":"Csicsvari","sequence":"additional","affiliation":[{"name":"Center for Molecular and Behavioral Neuroscience, Rutgers, State University of New Jersey, 197 University Avenue, Newark, NJ 07102"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gy\u00f6rgy","family":"Buzs\u00e1ki","sequence":"additional","affiliation":[{"name":"Center for Molecular and Behavioral Neuroscience, Rutgers, State University of New Jersey, 197 University Avenue, Newark, NJ 07102"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2001,7,24]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/36103"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0959-4388(95)80023-9"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(99)00044-3"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1971.0078"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(89)90423-5"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1037\/0033-295X.102.3.419"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(69)90092-3"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0173(83)90037-1"},{"key":"e_1_3_3_9_2","first-page":"235","volume-title":"Neuronal Ensembles. Strategies for Recording and Decoding","author":"Skaggs W E","year":"1998","unstructured":"W E Skaggs, B L McNaughton Neuronal Ensembles. Strategies for Recording and Decoding, eds H B Eichenbaum, J L Davis (Wiley, New York), pp. 235\u2013246 (1998)."},{"key":"e_1_3_3_10_2","volume-title":"Hippocampus As a Cognitive Map","author":"O'Keefe J","year":"1978","unstructured":"J O'Keefe, L Nadel Hippocampus As a Cognitive Map (Clarendon, Oxford, 1978)."},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.09-08-02907.1989"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-10-04090.1999"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8036517"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.271.5257.1870"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.274.5290.1216-a"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(08)61258-3"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0270(99)00124-7"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-01-00274.1999"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.1999.00446.x"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.07-07-01935.1987"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1997.0138"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2000.84.1.401"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.1999.00853.x"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00186-6"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.16.8918"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-21-09497.1999"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.14-10-06160.1994"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/17605"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/45154"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.161274398","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T01:36:24Z","timestamp":1649813784000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.161274398"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,7,24]]},"references-count":29,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2001,7,31]]}},"alternative-id":["10.1073\/pnas.161274398"],"URL":"https:\/\/doi.org\/10.1073\/pnas.161274398","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,7,24]]},"assertion":[{"value":"2001-05-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-06-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-07-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}