{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T06:24:30Z","timestamp":1779344670699,"version":"3.51.4"},"reference-count":30,"publisher":"Proceedings of the National Academy of Sciences","issue":"16","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2001,7,31]]},"abstract":"<jats:p>\n            The interaction of the multimodular heterogeneous nuclear ribonucleoprotein (hnRNP) K protein with many of its protein and nucleic acid partners is regulated by extracellular signals. Acting as a docking platform, K protein could link signal-transduction pathways to DNA- and RNA-directed processes such as transcription, mRNA processing, transport, and translation. Treatment of hepatocyte culture with insulin increased K protein tyrosine phosphorylation. Insulin altered K protein interaction with RNA and DNA\n            <jats:italic>in vitro.<\/jats:italic>\n            Administration of insulin into mice had similar effects on K protein in liver. Coimmunoprecipitations of RNA with K protein revealed preferential\n            <jats:italic>in vivo<\/jats:italic>\n            K protein binding of a subset of transcripts, including the insulin-inducible c-\n            <jats:italic>fos<\/jats:italic>\n            mRNA. These results suggest a class of insulin pathways that signal nucleic acid-directed processes that involve K protein.\n          <\/jats:p>","DOI":"10.1073\/pnas.161284098","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T14:34:10Z","timestamp":1027694050000},"page":"9044-9049","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":49,"title":["Insulin alters heterogeneous nuclear ribonucleoprotein K protein binding to DNA and RNA"],"prefix":"10.1073","volume":"98","author":[{"given":"J.","family":"Ostrowski","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Washington, Seattle, WA 98195; and Department of Gastroenterology, Medical Center for Postgraduate Education at the Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, 02-781 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Kawata","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Washington, Seattle, WA 98195; and Department of Gastroenterology, Medical Center for Postgraduate Education at the Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, 02-781 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. S.","family":"Schullery","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Washington, Seattle, WA 98195; and Department of Gastroenterology, Medical Center for Postgraduate Education at the Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, 02-781 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O. N.","family":"Denisenko","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Washington, Seattle, WA 98195; and Department of Gastroenterology, Medical Center for Postgraduate Education at the Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, 02-781 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Higaki","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Washington, Seattle, WA 98195; and Department of Gastroenterology, Medical Center for Postgraduate Education at the Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, 02-781 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. 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