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Epstein-Barr\n virus-associated B cell tumors are presumed to arise as a consequence of this\n virus-mediated B cell activation. The stage of B cell development represented\n by PEL, how this stage relates to tumor pathology, and how this information\n may be used to treat the disease are largely unknown. In this study we used\n gene expression profiling to order a range of B cell tumors by stage of\n development. PEL gene expression closely resembles that of malignant plasma\n cells, including the low expression of mature B cell genes. The unfolded\n protein response is partially activated in PEL, but is fully activated in\n plasma cell tumors, linking endoplasmic reticulum stress to plasma cell\n development through XBP-1. PEL cells can be defined by the overexpression of\n genes involved in inflammation, cell adhesion, and invasion, which may be\n responsible for their presentation in body cavities. Similar to malignant\n plasma cells, all PEL samples tested express the vitamin D receptor and are\n sensitive to the vitamin D analogue drug EB 1089 (Seocalcitol).<\/jats:p>","DOI":"10.1073\/pnas.1630810100","type":"journal-article","created":{"date-parts":[[2003,9,2]],"date-time":"2003-09-02T17:27:00Z","timestamp":1062523620000},"page":"10399-10404","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":165,"title":["Kaposi's sarcoma-associated herpesvirus-infected primary effusion lymphoma has a plasma cell gene expression profile"],"prefix":"10.1073","volume":"100","author":[{"given":"Richard G.","family":"Jenner","sequence":"first","affiliation":[{"name":"Wohl Virion Centre, Department of Immunology and\r Molecular Pathology, Windeyer Institute, University College London, London W1T\r 4JF, United Kingdom; Molecular Carcinogenesis\r Section, Institute for Cancer Research, Sutton, Surrey SM2 5NG, United\r Kingdom; and Cancer Research UK Viral Oncology\r Group, Wolfson Institute for Biomedical Research, University College London,\r London WC1E 6BT, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karine","family":"Maillard","sequence":"additional","affiliation":[{"name":"Wohl Virion Centre, Department of Immunology and\r Molecular Pathology, Windeyer Institute, University College London, London W1T\r 4JF, United Kingdom; Molecular Carcinogenesis\r Section, Institute for Cancer Research, Sutton, Surrey SM2 5NG, United\r Kingdom; and Cancer Research UK Viral Oncology\r Group, Wolfson Institute for Biomedical Research, University College London,\r London WC1E 6BT, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Cattini","sequence":"additional","affiliation":[{"name":"Wohl Virion Centre, Department of Immunology and\r Molecular Pathology, Windeyer Institute, University College London, London W1T\r 4JF, United Kingdom; Molecular Carcinogenesis\r Section, Institute for Cancer Research, Sutton, Surrey SM2 5NG, United\r Kingdom; and Cancer Research UK Viral Oncology\r Group, Wolfson Institute for Biomedical Research, University College London,\r London WC1E 6BT, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin A.","family":"Weiss","sequence":"additional","affiliation":[{"name":"Wohl Virion Centre, Department of Immunology and\r Molecular Pathology, Windeyer Institute, University College London, London W1T\r 4JF, United Kingdom; Molecular Carcinogenesis\r Section, Institute for Cancer Research, Sutton, Surrey SM2 5NG, United\r Kingdom; and Cancer Research UK Viral Oncology\r Group, Wolfson Institute for Biomedical Research, University College London,\r London WC1E 6BT, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"Boshoff","sequence":"additional","affiliation":[{"name":"Wohl Virion Centre, Department of Immunology and\r Molecular Pathology, Windeyer Institute, University College London, London W1T\r 4JF, United Kingdom; Molecular Carcinogenesis\r Section, Institute for Cancer Research, Sutton, Surrey SM2 5NG, United\r Kingdom; and Cancer Research UK Viral Oncology\r Group, Wolfson Institute for Biomedical Research, University College London,\r London WC1E 6BT, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Wooster","sequence":"additional","affiliation":[{"name":"Wohl Virion Centre, Department of Immunology and\r Molecular Pathology, Windeyer Institute, University College London, London W1T\r 4JF, United Kingdom; Molecular Carcinogenesis\r Section, Institute for Cancer Research, Sutton, Surrey SM2 5NG, United\r Kingdom; and Cancer Research UK Viral Oncology\r Group, Wolfson Institute for Biomedical Research, University College London,\r London WC1E 6BT, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Kellam","sequence":"additional","affiliation":[{"name":"Wohl Virion Centre, Department of Immunology and\r Molecular Pathology, Windeyer Institute, University College London, London W1T\r 4JF, United Kingdom; Molecular Carcinogenesis\r Section, Institute for Cancer Research, Sutton, Surrey SM2 5NG, United\r Kingdom; and Cancer Research UK Viral Oncology\r Group, Wolfson Institute for Biomedical Research, University College London,\r London WC1E 6BT, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"341","published-online":{"date-parts":[[2003,8,18]]},"reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7997879"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2000.0778"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199505043321802"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V86.4.1276.bloodjournal8641276"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V95.4.1406.004k26_1406_1412"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1006\/scbi.1998.0118"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(99)00214-3"},{"key":"e_1_3_2_8_2","first-page":"2511","volume":"2","year":"2001","unstructured":"Kieff, E. & Rickinson, A. 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