{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T22:24:22Z","timestamp":1769811862457,"version":"3.49.0"},"reference-count":16,"publisher":"Proceedings of the National Academy of Sciences","issue":"17","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2000,8,15]]},"abstract":"<jats:p>\n            Scan statistics are applied to combine information on multiple contiguous genetic markers used in a genome screen for susceptibility loci. This information may be, for example, allele sharing proportions for sib pairs or logarithm of odds (lod) scores in general small families. We focus on a dichotomous outcome variable, for example, case and control individuals or affected-affected versus affected-unaffected siblings, and suitable single-marker statistics. A significant scan statistic based on the single-marker statistics represents evidence of the presence of a susceptibility gene. For a given length of the scan statistic, we assess its significance by Monte Carlo permutation tests. Comparing\n            <jats:italic>P<\/jats:italic>\n            values for varying lengths of scan statistics, we treat the smallest observed\n            <jats:italic>P<\/jats:italic>\n            value as our statistic of interest and determine its overall significance level. We applied this method to a genome screen with autism families. The result was informative and surprising: A susceptibility region was found (genome-wide significance level,\n            <jats:italic>P<\/jats:italic>\n            = 0.038), which is missed with conventional approaches.\n          <\/jats:p>","DOI":"10.1073\/pnas.170179197","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T14:31:44Z","timestamp":1027693904000},"page":"9615-9617","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":83,"title":["Scan statistics to scan markers for susceptibility genes"],"prefix":"10.1073","volume":"97","author":[{"given":"J.","family":"Hoh","sequence":"first","affiliation":[{"name":"Laboratory of Statistical Genetics, Rockefeller University, 1230 York Avenue, New York, NY 10021"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Ott","sequence":"additional","affiliation":[{"name":"Laboratory of Statistical Genetics, Rockefeller University, 1230 York Avenue, New York, NY 10021"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"341","published-online":{"date-parts":[[2000,8,8]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1195-325"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/302697"},{"key":"e_1_3_3_3_2","first-page":"1347","volume":"58","author":"Kruglyak L","year":"1996","unstructured":"L Kruglyak, M J Daly, M P Reeve-Daly, E S Lander Am J Hum Genet 58, 1347\u20131363 (1996).","journal-title":"Am J Hum Genet"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/75514"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/514855"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2272(1997)14:6<785::AID-GEPI37>3.0.CO;2-K"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2272(1999)17:3<157::AID-GEPI1>3.0.CO;2-P"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4612-1578-3_1"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1621093"},{"key":"e_1_3_3_10_2","first-page":"353","volume":"53","author":"MacLean C J","year":"1993","unstructured":"C J MacLean, P C Sham, K S Kendler Am J Hum Genet 53, 353\u2013366 (1993).","journal-title":"Am J Hum Genet"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/6002"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.253.5018.390"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1195-241"},{"key":"e_1_3_3_14_2","volume-title":"Randomization, Bootstrap, and Monte Carlo Methods in Biology","author":"Manly B F J","year":"1998","unstructured":"B F J Manly Randomization, Bootstrap, and Monte Carlo Methods in Biology (Chapman & Hall, New York, 1998)."},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2272(1997)14:6<1023::AID-GEPI77>3.0.CO;2-K"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.26.15173"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.170179197","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T06:57:32Z","timestamp":1649833052000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.170179197"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,8,8]]},"references-count":16,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2000,8,15]]}},"alternative-id":["10.1073\/pnas.170179197"],"URL":"https:\/\/doi.org\/10.1073\/pnas.170179197","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,8,8]]},"assertion":[{"value":"2000-04-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2000-08-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}