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This result corroborates through rigorous data-driven statistical methods evidence emerging from previous studies about the role of\n                    <jats:italic>TRIB3<\/jats:italic>\n                    in modulating known mechanisms of neurodegeneration, such as neuronal death, cellular homeostasis, and interaction with established genes causing autosomal dominant Alzheimer\u2019s disease:\n                    <jats:italic>APP<\/jats:italic>\n                    and\n                    <jats:italic>PSEN1<\/jats:italic>\n                    . The developed integrated statistical\u2013experimental methodology could serve as a roadmap for investigations in other disorders.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1706100115","type":"journal-article","created":{"date-parts":[[2018,3,6]],"date-time":"2018-03-06T11:40:19Z","timestamp":1520336419000},"page":"3162-3167","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":48,"title":["Susceptibility of brain atrophy to\n                    <i>TRIB3<\/i>\n                    in Alzheimer\u2019s disease, evidence from functional prioritization in imaging genetics"],"prefix":"10.1073","volume":"115","author":[{"given":"Marco","family":"Lorenzi","sequence":"first","affiliation":[{"name":"Translational Imaging Group, Centre for Medical Image Computing, University College London, London WC1E 7JE, United Kingdom;"},{"name":"Epione Research Project, Universit\u00e9 C\u00f4te d\u2019Azur, BP 93 06 902 Inria Sophia Antipolis, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre","family":"Altmann","sequence":"additional","affiliation":[{"name":"Translational Imaging Group, Centre for Medical Image Computing, University College London, London WC1E 7JE, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Gutman","sequence":"additional","affiliation":[{"name":"Imaging Genetics Center, University of Southern California, Marina Del Rey, CA 90292;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selina","family":"Wray","sequence":"additional","affiliation":[{"name":"Department of Molecular Neuroscience, University College London Institute of Neurology, London WC1N 1PJ, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Arber","sequence":"additional","affiliation":[{"name":"Department of Molecular Neuroscience, University College London Institute of Neurology, London WC1N 1PJ, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derrek P.","family":"Hibar","sequence":"additional","affiliation":[{"name":"Imaging Genetics Center, University of Southern California, Marina Del Rey, CA 90292;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neda","family":"Jahanshad","sequence":"additional","affiliation":[{"name":"Imaging Genetics Center, University of Southern California, Marina Del Rey, CA 90292;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan M.","family":"Schott","sequence":"additional","affiliation":[{"name":"Department of Neurodegeneration, Dementia Research Centre, Institute of Neurology, London WC1N 3BG, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel C.","family":"Alexander","sequence":"additional","affiliation":[{"name":"Centre of Medical Image Computing, University College London, London WC1E 7JE, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Imaging Genetics Center, University of Southern California, Marina Del Rey, CA 90292;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastien","family":"Ourselin","sequence":"additional","affiliation":[{"name":"Translational Imaging Group, Centre for Medical Image Computing, University College London, London WC1E 7JE, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Alzheimer\u2019s Disease Neuroimaging Initiative","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2018,3,6]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1155\/2009\/609839","article-title":"Amyloid imaging in aging and dementia: Testing the amyloid hypothesis in vivo","volume":"21","author":"Rabinovici GD","year":"2009","unstructured":"GD Rabinovici, WJ Jagust, Amyloid imaging in aging and dementia: Testing the amyloid hypothesis in vivo. 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