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IL-22RA2 shares amino acid sequence homology with IL-22RA1 (also known as IL-22R, zcytor11, and CRF2\u20139) and is physically adjacent to IL-20R\u03b1 and IFN-\u03b3R1 on chromosome 6q23.3\u201324.2. We demonstrate that IL-22RA2 binds specifically to IL-22 and neutralizes IL-22-induced proliferation of BaF3 cells expressing IL-22 receptor subunits. IL-22RA2 mRNA is highly expressed in placenta and spleen by Northern blotting. PCR analysis using RNA from various tissues and cell lines showed that IL-22RA2 was expressed in a range of tissues, including those in the digestive, female reproductive, and immune systems.<jats:italic>In situ<\/jats:italic>hybridization revealed the dominant cell types expressing IL-22RA2 were mononuclear cells and epithelium. Because IL-22 induces the expression of acute phase reactants, IL-22RA2 may play an important role as an IL-22 antagonist in the regulation of inflammatory responses.<\/jats:p>","DOI":"10.1073\/pnas.171303198","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T14:37:36Z","timestamp":1027694256000},"page":"9511-9516","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":187,"title":["A soluble class II cytokine receptor, IL-22RA2, is a naturally occurring IL-22 antagonist"],"prefix":"10.1073","volume":"98","author":[{"given":"Wenfeng","family":"Xu","sequence":"first","affiliation":[{"name":"ZymoGenetics Inc., 1201 Eastlake Avenue East, Seattle, WA 98102"}]},{"given":"Scott R.","family":"Presnell","sequence":"additional","affiliation":[{"name":"ZymoGenetics Inc., 1201 Eastlake Avenue East, Seattle, WA 98102"}]},{"given":"Julia","family":"Parrish-Novak","sequence":"additional","affiliation":[{"name":"ZymoGenetics Inc., 1201 Eastlake Avenue East, Seattle, WA 98102"}]},{"given":"Wayne","family":"Kindsvogel","sequence":"additional","affiliation":[{"name":"ZymoGenetics Inc., 1201 Eastlake Avenue East, Seattle, WA 98102"}]},{"given":"Steve","family":"Jaspers","sequence":"additional","affiliation":[{"name":"ZymoGenetics Inc., 1201 Eastlake Avenue East, Seattle, WA 98102"}]},{"given":"Zhi","family":"Chen","sequence":"additional","affiliation":[{"name":"ZymoGenetics Inc., 1201 Eastlake Avenue East, Seattle, WA 98102"}]},{"given":"Stacey R.","family":"Dillon","sequence":"additional","affiliation":[{"name":"ZymoGenetics Inc., 1201 Eastlake Avenue East, Seattle, WA 98102"}]},{"given":"Zeren","family":"Gao","sequence":"additional","affiliation":[{"name":"ZymoGenetics Inc., 1201 Eastlake Avenue East, Seattle, WA 98102"}]},{"given":"Teresa","family":"Gilbert","sequence":"additional","affiliation":[{"name":"ZymoGenetics Inc., 1201 Eastlake Avenue East, Seattle, WA 98102"}]},{"given":"Karen","family":"Madden","sequence":"additional","affiliation":[{"name":"ZymoGenetics Inc., 1201 Eastlake Avenue East, Seattle, WA 98102"}]},{"given":"Stacy","family":"Schlutsmeyer","sequence":"additional","affiliation":[{"name":"ZymoGenetics Inc., 1201 Eastlake Avenue East, Seattle, WA 98102"}]},{"given":"Lena","family":"Yao","sequence":"additional","affiliation":[{"name":"ZymoGenetics Inc., 1201 Eastlake Avenue East, Seattle, WA 98102"}]},{"given":"Theodore E.","family":"Whitmore","sequence":"additional","affiliation":[{"name":"ZymoGenetics Inc., 1201 Eastlake Avenue East, Seattle, WA 98102"}]},{"given":"Yasmin","family":"Chandrasekher","sequence":"additional","affiliation":[{"name":"ZymoGenetics Inc., 1201 Eastlake Avenue East, Seattle, WA 98102"}]},{"given":"Francis J.","family":"Grant","sequence":"additional","affiliation":[{"name":"ZymoGenetics Inc., 1201 Eastlake Avenue East, Seattle, WA 98102"}]},{"given":"Mark","family":"Maurer","sequence":"additional","affiliation":[{"name":"ZymoGenetics Inc., 1201 Eastlake Avenue East, Seattle, WA 98102"}]},{"given":"Laura","family":"Jelinek","sequence":"additional","affiliation":[{"name":"ZymoGenetics Inc., 1201 Eastlake Avenue East, Seattle, WA 98102"}]},{"given":"Harold","family":"Storey","sequence":"additional","affiliation":[{"name":"ZymoGenetics Inc., 1201 Eastlake Avenue East, Seattle, WA 98102"}]},{"given":"Ty","family":"Brender","sequence":"additional","affiliation":[{"name":"ZymoGenetics Inc., 1201 Eastlake Avenue East, Seattle, WA 98102"}]},{"given":"Angie","family":"Hammond","sequence":"additional","affiliation":[{"name":"ZymoGenetics Inc., 1201 Eastlake Avenue East, Seattle, WA 98102"}]},{"given":"Stavros","family":"Topouzis","sequence":"additional","affiliation":[{"name":"ZymoGenetics Inc., 1201 Eastlake Avenue East, Seattle, WA 98102"}]},{"given":"Christopher H.","family":"Clegg","sequence":"additional","affiliation":[{"name":"ZymoGenetics Inc., 1201 Eastlake Avenue East, Seattle, WA 98102"}]},{"given":"Donald C.","family":"Foster","sequence":"additional","affiliation":[{"name":"ZymoGenetics Inc., 1201 Eastlake Avenue East, Seattle, WA 98102"}]}],"member":"341","published-online":{"date-parts":[[2001,7,31]]},"reference":[{"key":"e_1_3_4_1_2","unstructured":"Rosen C. 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