{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T16:41:58Z","timestamp":1781109718131,"version":"3.54.1"},"reference-count":37,"publisher":"National Academy of Sciences","issue":"19","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2002,9,17]]},"abstract":"<jats:p>\n                    We used a combination of bioinformatics, electron cryomicroscopy, and biochemical techniques to identify an oxidoreductase-like domain in the skeletal muscle Ca\n                    <jats:sup>2+<\/jats:sup>\n                    release channel protein (RyR1). The initial prediction was derived from sequence-based fold recognition for the N-terminal region (41\u2013420) of RyR1. The putative domain was computationally localized to the clamp domain in the cytoplasmic region of a 22\u212b structure of RyR1. This localization was subsequently confirmed by difference imaging with a sequence specific antibody. Consistent with the prediction of an oxidoreductase domain, RyR1 binds [\n                    <jats:sup>3<\/jats:sup>\n                    H]NAD\n                    <jats:sup>+<\/jats:sup>\n                    , supporting a model in which RyR1 has a oxidoreductase-like domain that could function as a type of redox sensor.\n                  <\/jats:p>","DOI":"10.1073\/pnas.182058899","type":"journal-article","created":{"date-parts":[[2002,9,17]],"date-time":"2002-09-17T12:40:55Z","timestamp":1032266455000},"page":"12155-12160","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":56,"title":["The skeletal muscle Ca\n                    <sup>2+<\/sup>\n                    release channel has an oxidoreductase-like domain"],"prefix":"10.1073","volume":"99","author":[{"given":"Matthew L.","family":"Baker","sequence":"first","affiliation":[{"name":"Program in Structural and Computational Biology and Molecular Biophysics, National Center for Macromolecular Imaging, Verna and Marrs McLean Department of Biochemistry and Molecular Biology, and Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina I.","family":"Serysheva","sequence":"additional","affiliation":[{"name":"Program in Structural and Computational Biology and Molecular Biophysics, National Center for Macromolecular Imaging, Verna and Marrs McLean Department of Biochemistry and Molecular Biology, and Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serap","family":"Sencer","sequence":"additional","affiliation":[{"name":"Program in Structural and Computational Biology and Molecular Biophysics, National Center for Macromolecular Imaging, Verna and Marrs McLean Department of Biochemistry and Molecular Biology, and Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yili","family":"Wu","sequence":"additional","affiliation":[{"name":"Program in Structural and Computational Biology and Molecular Biophysics, National Center for Macromolecular Imaging, Verna and Marrs McLean Department of Biochemistry and Molecular Biology, and Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven J.","family":"Ludtke","sequence":"additional","affiliation":[{"name":"Program in Structural and Computational Biology and Molecular Biophysics, National Center for Macromolecular Imaging, Verna and Marrs McLean Department of Biochemistry and Molecular Biology, and Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Jiang","sequence":"additional","affiliation":[{"name":"Program in Structural and Computational Biology and Molecular Biophysics, National Center for Macromolecular Imaging, Verna and Marrs McLean Department of Biochemistry and Molecular Biology, and Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan L.","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Program in Structural and Computational Biology and Molecular Biophysics, National Center for Macromolecular Imaging, Verna and Marrs McLean Department of Biochemistry and Molecular Biology, and Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 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