{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T21:44:25Z","timestamp":1776289465202,"version":"3.50.1"},"reference-count":46,"publisher":"Proceedings of the National Academy of Sciences","issue":"18","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2002,9,3]]},"abstract":"<jats:p>\n                    The nuclease hypersensitivity element III\n                    <jats:sub>1<\/jats:sub>\n                    upstream of the P1 promoter of c-\n                    <jats:italic>MYC<\/jats:italic>\n                    controls 85\u201390% of the transcriptional activation of this gene. We have demonstrated that the purine-rich strand of the DNA in this region can form two different intramolecular G-quadruplex structures, only one of which seems to be biologically relevant. This biologically relevant structure is the kinetically favored chair-form G-quadruplex, which is destabilized when mutated with a single G \u2192 A transition, resulting in a 3-fold increase in basal transcriptional activity of the c-\n                    <jats:italic>MYC<\/jats:italic>\n                    promoter. The cationic porphyrin TMPyP4, which has been shown to stabilize this G-quadruplex structure, is able to suppress further c-\n                    <jats:italic>MYC<\/jats:italic>\n                    transcriptional activation. These results provide compelling evidence that a specific G-quadruplex structure formed in the c-\n                    <jats:italic>MYC<\/jats:italic>\n                    promoter region functions as a transcriptional repressor element. Furthermore, we establish the principle that c-\n                    <jats:italic>MYC<\/jats:italic>\n                    transcription can be controlled by ligand-mediated G-quadruplex stabilization.\n                  <\/jats:p>","DOI":"10.1073\/pnas.182256799","type":"journal-article","created":{"date-parts":[[2002,9,3]],"date-time":"2002-09-03T15:58:55Z","timestamp":1031068735000},"page":"11593-11598","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":2025,"title":["Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-\n                    <i>MYC<\/i>\n                    transcription"],"prefix":"10.1073","volume":"99","author":[{"given":"Adam","family":"Siddiqui-Jain","sequence":"first","affiliation":[{"name":"College of Pharmacy and Department of Chemistry, University of Arizona, Tucson, AZ 85721; and Arizona Cancer Center, 1515 North Campbell Avenue, Tucson, AZ 85724"}]},{"given":"Cory L.","family":"Grand","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Department of Chemistry, University of Arizona, Tucson, AZ 85721; and Arizona Cancer Center, 1515 North Campbell Avenue, Tucson, AZ 85724"}]},{"given":"David J.","family":"Bearss","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Department of Chemistry, University of Arizona, Tucson, AZ 85721; and Arizona Cancer Center, 1515 North Campbell Avenue, Tucson, AZ 85724"}]},{"given":"Laurence H.","family":"Hurley","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Department of Chemistry, University of Arizona, Tucson, AZ 85721; and Arizona Cancer Center, 1515 North Campbell Avenue, Tucson, AZ 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