{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T04:48:17Z","timestamp":1776487697473,"version":"3.51.2"},"reference-count":35,"publisher":"Proceedings of the National Academy of Sciences","issue":"21","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2000,10,10]]},"abstract":"<jats:p>A transgenic (Tg) mouse expressing human IL-15 was generated to define the role of IL-15 in the normal immune response. Overexpression of IL-15 resulted in an increase of NK, CD44<jats:sup>hi<\/jats:sup>CD8 memory T cells, and \u03b3\u03b4 T cells. Additionally, we observed the emergence of a novel type of NK-T cells with CD8\u03b1\u03b1\u2032 expression. Due to the expansion and activation of NK cells, the IL-15Tg mouse showed enhanced innate immunity. In adaptive T cell immunity, the roles of IL-15 contrasted with those of IL-2. IL-15 inhibited IL-2-induced T cell death, which plays a role in the maintenance of peripheral self-tolerance. IL-15 thus seems to contribute to enhanced immune memory by selectively propagating memory T cells and by blocking T cell death mediated by IL-2.<\/jats:p>","DOI":"10.1073\/pnas.200363097","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T14:31:39Z","timestamp":1027693899000},"page":"11445-11450","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":354,"title":["IL-2-induced activation-induced cell death is inhibited in IL-15 transgenic mice"],"prefix":"10.1073","volume":"97","author":[{"given":"Joanna","family":"Marks-Konczalik","sequence":"first","affiliation":[{"name":"Metabolism Branch, Division of Clinical Sciences, Laboratory of Tumor Immunology and Biology, Division of Basic Sciences, Dermatology Branch, Division of Clinical Sciences, and Transgenic Mouse Model, Science Applications International Corporation Frederick, Frederick Cancer Research and Development Center, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sigrid","family":"Dubois","sequence":"additional","affiliation":[{"name":"Metabolism Branch, Division of Clinical Sciences, Laboratory of Tumor Immunology and Biology, Division of Basic Sciences, Dermatology Branch, Division of Clinical Sciences, and Transgenic Mouse Model, Science Applications International Corporation Frederick, Frederick Cancer Research and Development Center, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline M.","family":"Losi","sequence":"additional","affiliation":[{"name":"Metabolism Branch, Division of Clinical Sciences, Laboratory of Tumor Immunology and Biology, Division of Basic Sciences, Dermatology Branch, Division of Clinical Sciences, and Transgenic Mouse Model, Science Applications International Corporation Frederick, Frederick Cancer Research and Development Center, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Sabzevari","sequence":"additional","affiliation":[{"name":"Metabolism Branch, Division of Clinical Sciences, Laboratory of Tumor Immunology and Biology, Division of Basic Sciences, Dermatology Branch, Division of Clinical Sciences, and Transgenic Mouse Model, Science Applications International Corporation Frederick, Frederick Cancer Research and Development Center, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuo","family":"Yamada","sequence":"additional","affiliation":[{"name":"Metabolism Branch, Division of Clinical Sciences, Laboratory of Tumor Immunology and Biology, Division of Basic Sciences, Dermatology Branch, Division of Clinical Sciences, and Transgenic Mouse Model, Science Applications International Corporation Frederick, Frederick Cancer Research and Development Center, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lionel","family":"Feigenbaum","sequence":"additional","affiliation":[{"name":"Metabolism Branch, Division of Clinical Sciences, Laboratory of Tumor Immunology and Biology, Division of Basic Sciences, Dermatology Branch, Division of Clinical Sciences, and Transgenic Mouse Model, Science Applications International Corporation Frederick, Frederick Cancer Research and Development Center, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas A.","family":"Waldmann","sequence":"additional","affiliation":[{"name":"Metabolism Branch, Division of Clinical Sciences, Laboratory of Tumor Immunology and Biology, Division of Basic Sciences, Dermatology Branch, Division of Clinical Sciences, and Transgenic Mouse Model, Science Applications International Corporation Frederick, Frederick Cancer Research and Development Center, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Tagaya","sequence":"additional","affiliation":[{"name":"Metabolism Branch, Division of Clinical Sciences, Laboratory of Tumor Immunology and Biology, Division of Basic Sciences, Dermatology Branch, Division of Clinical Sciences, and Transgenic Mouse Model, Science Applications International Corporation Frederick, Frederick Cancer Research and Development Center, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"341","published-online":{"date-parts":[[2000,10,3]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.11.4935"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.11.4940"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8178155"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1995.tb00035.x"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.17.1.19"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.7.2897"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12326630"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12338641"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/35636"},{"key":"e_1_3_3_10_2","doi-asserted-by":"crossref","first-page":"5931","DOI":"10.4049\/jimmunol.159.12.5931","volume":"159","author":"Ohteki T","year":"1997","unstructured":"T Ohteki, S Ho, H Suzuki, T W Mak, P S Ohashi J Immunol 159, 5931\u20135935 (1997).","journal-title":"J Immunol"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.187.6.967"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80246-0"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1996.tb00873.x"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/1074-7613(95)90180-9"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80664-0"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8235625"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.191.5.771"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.191.5.753"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80564-6"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/353858a0"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.288.5466.675"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)83619-5"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(91)90325-A"},{"key":"e_1_3_3_24_2","doi-asserted-by":"crossref","first-page":"4418","DOI":"10.4049\/jimmunol.160.9.4418","volume":"160","author":"Bamford R N","year":"1998","unstructured":"R N Bamford, A P DeFilippis, N Azimi, G Kurys, T A Waldmann J Immunol 160, 4418\u20134426 (1998).","journal-title":"J Immunol"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.26.14444"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.180.4.1395"},{"key":"e_1_3_3_27_2","doi-asserted-by":"crossref","first-page":"4282","DOI":"10.4049\/jimmunol.157.10.4282","volume":"157","author":"Puzanov I J","year":"1996","unstructured":"I J Puzanov, M Bennett, V Kumar J Immunol 157, 4282\u20134285 (1996).","journal-title":"J Immunol"},{"key":"e_1_3_3_28_2","doi-asserted-by":"crossref","first-page":"663","DOI":"10.4049\/jimmunol.156.2.663","volume":"156","author":"Nishimura H","year":"1996","unstructured":"H Nishimura, K Hiromatsu, N Kobayashi, K H Grabstein, R Paxton, K Sugamura, J A Bluestone, Y Yoshikai J Immunol 156, 663\u2013669 (1996).","journal-title":"J Immunol"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7907820"},{"key":"e_1_3_3_30_2","doi-asserted-by":"crossref","first-page":"17","DOI":"10.4049\/jimmunol.150.1.17","volume":"150","author":"Ballas Z K","year":"1993","unstructured":"Z K Ballas, W Rasmussen J Immunol 150, 17\u201330 (1993).","journal-title":"J Immunol"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1097-1124"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.17.1.221"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/1.2.113"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.170.4.1103"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(97)01205-X"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.200363097","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T04:41:15Z","timestamp":1704343275000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.200363097"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,10,3]]},"references-count":35,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2000,10,10]]}},"alternative-id":["10.1073\/pnas.200363097"],"URL":"https:\/\/doi.org\/10.1073\/pnas.200363097","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,10,3]]},"assertion":[{"value":"2000-08-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2000-10-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}