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The surrogate light chain\/GAL1 association is a direct protein\u2013protein interaction (<jats:italic>K<\/jats:italic><jats:sub>a<\/jats:sub>= 2 \u00d7 10<jats:sup>6<\/jats:sup>M<jats:sup>\u22121<\/jats:sup>), and the NH<jats:sub>2<\/jats:sub>extra loop of \u03bb-like is the major binding element. Pre-BCR binding to stromal cells depends upon GAL1 anchoring to glycosylated counter-receptors, and these complexes completely relocalize to form a synapse at the contact zone between preB and stromal cells. This immune developmental synapse is accompanied by the initiation of intracellular tyrosine kinase activity and signal transduction from the pre-BCR.<\/jats:p>","DOI":"10.1073\/pnas.202323999","type":"journal-article","created":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T16:58:07Z","timestamp":1033491487000},"page":"13014-13019","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":197,"title":["Galectin-1 is a stromal cell ligand of the pre-B cell receptor (BCR) implicated in synapse formation between pre-B and stromal cells and in pre-BCR triggering"],"prefix":"10.1073","volume":"99","author":[{"given":"Laurent","family":"Gauthier","sequence":"first","affiliation":[{"name":"Centre d'Immunologie de Marseille-Luminy, Centre National de la Recherche Scientifique-Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale -Universit\u00e9 M\u00e9diterran\u00e9e, Campus de Luminy, Case 906, 13288 Marseille Cedex 09, France; and Laboratoire de Chimie des Prot\u00e9ines, Commissariat \u00e0 l'Energie Atomique, 38054 Grenoble Cedex 9, France"}]},{"given":"Benjamin","family":"Rossi","sequence":"additional","affiliation":[{"name":"Centre d'Immunologie de Marseille-Luminy, Centre National de la Recherche Scientifique-Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale -Universit\u00e9 M\u00e9diterran\u00e9e, Campus de Luminy, Case 906, 13288 Marseille Cedex 09, France; and Laboratoire de Chimie des Prot\u00e9ines, Commissariat \u00e0 l'Energie Atomique, 38054 Grenoble Cedex 9, France"}]},{"given":"Florence","family":"Roux","sequence":"additional","affiliation":[{"name":"Centre d'Immunologie de Marseille-Luminy, Centre National de la Recherche Scientifique-Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale -Universit\u00e9 M\u00e9diterran\u00e9e, Campus de Luminy, Case 906, 13288 Marseille Cedex 09, France; and Laboratoire de Chimie des Prot\u00e9ines, Commissariat \u00e0 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