{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T21:20:04Z","timestamp":1770499204004,"version":"3.49.0"},"reference-count":21,"publisher":"Proceedings of the National Academy of Sciences","issue":"20","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2002,10]]},"abstract":"<jats:p>c-maf is a T helper (Th)2 cell-specific transcription factor, which promotes the differentiation of Th2 cells mainly by an IL-4-dependent mechanism. It remains unclear whether c-maf possesses any IL-4-independent function in regulating the production of Th2 cytokines. Here, we provide evidence demonstrating that c-maf, independent of IL-4, is essential for normal induction of CD25 in developing Th2 cells. The levels of CD25 are significantly higher in developing Th2 cells than in developing Th1 cells during<jats:italic>in vitro<\/jats:italic>differentiation. In addition, timely blockade of IL-2 receptor signaling selectively inhibits the production of Th2 cytokines, but not IFN-\u03b3 or IL-2. Taken together, our results uncover an IL-4-independent and CD25-mediated function of c-maf in promoting the production of Th2 cytokines.<\/jats:p>","DOI":"10.1073\/pnas.202474499","type":"journal-article","created":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T16:58:28Z","timestamp":1033491508000},"page":"13026-13030","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":51,"title":["An IL-4-independent and CD25-mediated function of c-maf in promoting the production of Th2 cytokines"],"prefix":"10.1073","volume":"99","author":[{"given":"Eun Sook","family":"Hwang","sequence":"first","affiliation":[{"name":"Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA 02115; and Department of Medicine, Harvard Medical School, Boston, MA 02115"}]},{"given":"Ian Alexander","family":"White","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115; 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