{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T01:11:49Z","timestamp":1768439509723,"version":"3.49.0"},"reference-count":57,"publisher":"Proceedings of the National Academy of Sciences","issue":"22","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2002,10,29]]},"abstract":"<jats:p>\n            The kinesin superfamily proteins (KIFs) play essential roles in receptor transportation along the microtubules. KIF17 transports the\n            <jats:italic>N<\/jats:italic>\n            -methyl-\n            <jats:sc>d<\/jats:sc>\n            -aspartate receptor NR2B subunit\n            <jats:italic>in vitro<\/jats:italic>\n            , but its role\n            <jats:italic>in vivo<\/jats:italic>\n            is unknown. To clarify this role, we generated transgenic mice overexpressing KIF17 tagged with GFP. The KIF17 transgenic mice exhibited enhanced learning and memory in a series of behavioral tasks, up-regulated NR2B expression with the potential involvement of a transcriptional factor, the cAMP-dependent response element-binding protein, and increased phosphorylation of the cAMP-dependent response element-binding protein. Our results suggest that the motor protein KIF17 contributes to neuronal events required for learning and memory by trafficking fundamental\n            <jats:italic>N<\/jats:italic>\n            -methyl-\n            <jats:sc>d<\/jats:sc>\n            -aspartate-type glutamate receptors.\n          <\/jats:p>","DOI":"10.1073\/pnas.222371099","type":"journal-article","created":{"date-parts":[[2002,10,29]],"date-time":"2002-10-29T17:24:11Z","timestamp":1035912251000},"page":"14500-14505","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":156,"title":["Overexpression of motor protein KIF17 enhances spatial and working memory in transgenic mice"],"prefix":"10.1073","volume":"99","author":[{"given":"Richard Wing-Chuen","family":"Wong","sequence":"first","affiliation":[{"name":"Department of Cell Biology and Anatomy, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan"}]},{"given":"Mitsutoshi","family":"Setou","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Anatomy, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan"}]},{"given":"Junlin","family":"Teng","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Anatomy, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan"}]},{"given":"Yosuke","family":"Takei","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Anatomy, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan"}]},{"given":"Nobutaka","family":"Hirokawa","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Anatomy, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan"}]}],"member":"341","published-online":{"date-parts":[[2002,10,21]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.279.5350.519"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(98)80087-2"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.119.5.1287"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.18.9654"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.111145398"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.288.5472.1796"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81736-5"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.50.31459"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1329206"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.256.5060.1217"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1067020"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/361031a0"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(95)80016-U"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00321-X"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0962-8924(01)02073-6"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(01)00122-8"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/43432"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.274.5293.1678"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/29.7.e39"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-11-04177.1998"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1385\/MB:15:2:155"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M001965200"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1385\/MB:15:1:65"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M004189200"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00497-4"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/11.5.1475"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00585-2"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/297681a0"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/35050103"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81827-9"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-9525(99)01846-6"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(98)00005-5"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.94.1.129"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90691-0"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/0962-8924(96)10003-9"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200207163"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(85)80099-4"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/317073a0"},{"key":"e_1_3_3_39_2","first-page":"380","volume":"41","author":"Olton D. S.","year":"1981","unstructured":"Olton D. S. & Feustle, W. A. (1981) Exp. Brain Res.41,380-389.7215498","journal-title":"Exp. Brain Res."},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/0163-1047(93)90664-4"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-15-05853.2000"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1063(1998)8:3<205::AID-HIPO3>3.0.CO;2-I"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3932(79)90042-3"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1997.0136"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2001.0945"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00686-4"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(96)80082-1"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.21.1.127"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(97)00050-7"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1007\/s000180050314"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn819"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00684-0"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00657-8"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1126\/stke.2001.82.pe1"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/35085068"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7696(01)04005-0"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(00)00129-X"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.222371099","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T01:08:25Z","timestamp":1650935305000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.222371099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,10,21]]},"references-count":57,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2002,10,29]]}},"alternative-id":["10.1073\/pnas.222371099"],"URL":"https:\/\/doi.org\/10.1073\/pnas.222371099","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,10,21]]},"assertion":[{"value":"2002-06-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2002-10-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}