{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T16:29:02Z","timestamp":1761236942403},"reference-count":34,"publisher":"Proceedings of the National Academy of Sciences","issue":"1","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2003,1,7]]},"abstract":"<jats:p>Single-nucleotide polymorphisms (SNPs) constitute the great majority of variations in the human genome, and as heritable variable landmarks they are useful markers for disease mapping and resolving population structure. Redundant coverage in overlaps of large-insert genomic clones, sequenced as part of the Human Genome Project, comprises a quarter of the genome, and it is representative in terms of base compositional and functional sequence features. We mined these regions to produce 500,000 high-confidence SNP candidates as a uniform resource for describing nucleotide diversity and its regional variation within the genome. Distributions of marker density observed at different overlap length scales under a model of recombination and population size change show that the history of the population represented by the public genome sequence is one of collapse followed by a recent phase of mild size recovery. The inferred times of collapse and recovery are Upper Paleolithic, in agreement with archaeological evidence of the initial modern human colonization of Europe.<\/jats:p>","DOI":"10.1073\/pnas.222673099","type":"journal-article","created":{"date-parts":[[2003,1,7]],"date-time":"2003-01-07T17:22:42Z","timestamp":1041960162000},"page":"376-381","update-policy":"http:\/\/dx.doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":78,"title":["Sequence variations in the public human genome data reflect a bottlenecked population history"],"prefix":"10.1073","volume":"100","author":[{"given":"Gabor","family":"Marth","sequence":"first","affiliation":[{"name":"National Center for Biotechnology Information, National Institutes of Health, Bethesda, MD 20894; Department of Genetics, Washington University School of Medicine, St. Louis, MO 63130; Division of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63130; Department of Molecular Biology and Genetics and McKusick\u2013Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Anthropology, University of Utah, Salt Lake..."}]},{"given":"Greg","family":"Schuler","sequence":"additional","affiliation":[{"name":"National Center for Biotechnology Information, National Institutes of Health, Bethesda, MD 20894; Department of Genetics, Washington University School of Medicine, St. Louis, MO 63130; Division of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63130; Department of Molecular Biology and Genetics and McKusick\u2013Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Anthropology, University of Utah, Salt Lake..."}]},{"given":"Raymond","family":"Yeh","sequence":"additional","affiliation":[{"name":"National Center for Biotechnology Information, National Institutes of Health, Bethesda, MD 20894; Department of Genetics, Washington University School of Medicine, St. Louis, MO 63130; Division of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63130; Department of Molecular Biology and Genetics and McKusick\u2013Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Anthropology, University of Utah, Salt Lake..."}]},{"given":"Ruth","family":"Davenport","sequence":"additional","affiliation":[{"name":"National Center for Biotechnology Information, National Institutes of Health, Bethesda, MD 20894; Department of Genetics, Washington University School of Medicine, St. Louis, MO 63130; Division of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63130; Department of Molecular Biology and Genetics and McKusick\u2013Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Anthropology, University of Utah, Salt Lake..."}]},{"given":"Richa","family":"Agarwala","sequence":"additional","affiliation":[{"name":"National Center for Biotechnology Information, National Institutes of Health, Bethesda, MD 20894; Department of Genetics, Washington University School of Medicine, St. Louis, MO 63130; Division of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63130; Department of Molecular Biology and Genetics and McKusick\u2013Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Anthropology, University of Utah, Salt Lake..."}]},{"given":"Deanna","family":"Church","sequence":"additional","affiliation":[{"name":"National Center for Biotechnology Information, National Institutes of Health, Bethesda, MD 20894; Department of Genetics, Washington University School of Medicine, St. Louis, MO 63130; Division of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63130; Department of Molecular Biology and Genetics and McKusick\u2013Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Anthropology, University of Utah, Salt Lake..."}]},{"given":"Sarah","family":"Wheelan","sequence":"additional","affiliation":[{"name":"National Center for Biotechnology Information, National Institutes of Health, Bethesda, MD 20894; Department of Genetics, Washington University School of Medicine, St. Louis, MO 63130; Division of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63130; Department of Molecular Biology and Genetics and McKusick\u2013Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Anthropology, University of Utah, Salt Lake..."}]},{"given":"Jonathan","family":"Baker","sequence":"additional","affiliation":[{"name":"National Center for Biotechnology Information, National Institutes of Health, Bethesda, MD 20894; Department of Genetics, Washington University School of Medicine, St. Louis, MO 63130; Division of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63130; Department of Molecular Biology and Genetics and McKusick\u2013Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Anthropology, University of Utah, Salt Lake..."}]},{"given":"Ming","family":"Ward","sequence":"additional","affiliation":[{"name":"National Center for Biotechnology Information, National Institutes of Health, Bethesda, MD 20894; Department of Genetics, Washington University School of Medicine, St. Louis, MO 63130; Division of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63130; Department of Molecular Biology and Genetics and McKusick\u2013Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Anthropology, University of Utah, Salt Lake..."}]},{"given":"Michael","family":"Kholodov","sequence":"additional","affiliation":[{"name":"National Center for Biotechnology Information, National Institutes of Health, Bethesda, MD 20894; Department of Genetics, Washington University School of Medicine, St. Louis, MO 63130; Division of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63130; Department of Molecular Biology and Genetics and McKusick\u2013Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Anthropology, University of Utah, Salt Lake..."}]},{"given":"Lon","family":"Phan","sequence":"additional","affiliation":[{"name":"National Center for Biotechnology Information, National Institutes of Health, Bethesda, MD 20894; Department of Genetics, Washington University School of Medicine, St. Louis, MO 63130; Division of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63130; Department of Molecular Biology and Genetics and McKusick\u2013Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Anthropology, University of Utah, Salt Lake..."}]},{"given":"Eva","family":"Czabarka","sequence":"additional","affiliation":[{"name":"National Center for Biotechnology Information, National Institutes of Health, Bethesda, MD 20894; Department of Genetics, Washington University School of Medicine, St. Louis, MO 63130; Division of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63130; Department of Molecular Biology and Genetics and McKusick\u2013Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Anthropology, University of Utah, Salt Lake..."}]},{"given":"Janos","family":"Murvai","sequence":"additional","affiliation":[{"name":"National Center for Biotechnology Information, National Institutes of Health, Bethesda, MD 20894; Department of Genetics, Washington University School of Medicine, St. Louis, MO 63130; Division of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63130; Department of Molecular Biology and Genetics and McKusick\u2013Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Anthropology, University of Utah, Salt Lake..."}]},{"given":"David","family":"Cutler","sequence":"additional","affiliation":[{"name":"National Center for Biotechnology Information, National Institutes of Health, Bethesda, MD 20894; Department of Genetics, Washington University School of Medicine, St. Louis, MO 63130; Division of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63130; Department of Molecular Biology and Genetics and McKusick\u2013Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Anthropology, University of Utah, Salt Lake..."}]},{"given":"Stephen","family":"Wooding","sequence":"additional","affiliation":[{"name":"National Center for Biotechnology Information, National Institutes of Health, Bethesda, MD 20894; Department of Genetics, Washington University School of Medicine, St. Louis, MO 63130; Division of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63130; Department of Molecular Biology and Genetics and McKusick\u2013Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Anthropology, University of Utah, Salt Lake..."}]},{"given":"Alan","family":"Rogers","sequence":"additional","affiliation":[{"name":"National Center for Biotechnology Information, National Institutes of Health, Bethesda, MD 20894; Department of Genetics, Washington University School of Medicine, St. Louis, MO 63130; Division of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63130; Department of Molecular Biology and Genetics and McKusick\u2013Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Anthropology, University of Utah, Salt Lake..."}]},{"given":"Aravinda","family":"Chakravarti","sequence":"additional","affiliation":[{"name":"National Center for Biotechnology Information, National Institutes of Health, Bethesda, MD 20894; Department of Genetics, Washington University School of Medicine, St. Louis, MO 63130; Division of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63130; Department of Molecular Biology and Genetics and McKusick\u2013Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Anthropology, University of Utah, Salt Lake..."}]},{"given":"Henry C.","family":"Harpending","sequence":"additional","affiliation":[{"name":"National Center for Biotechnology Information, National Institutes of Health, Bethesda, MD 20894; Department of Genetics, Washington University School of Medicine, St. Louis, MO 63130; Division of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63130; Department of Molecular Biology and Genetics and McKusick\u2013Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Anthropology, University of Utah, Salt Lake..."}]},{"given":"Pui-Yan","family":"Kwok","sequence":"additional","affiliation":[{"name":"National Center for Biotechnology Information, National Institutes of Health, Bethesda, MD 20894; Department of Genetics, Washington University School of Medicine, St. Louis, MO 63130; Division of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63130; Department of Molecular Biology and Genetics and McKusick\u2013Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Anthropology, University of Utah, Salt Lake..."}]},{"given":"Stephen T.","family":"Sherry","sequence":"additional","affiliation":[{"name":"National Center for Biotechnology Information, National Institutes of Health, Bethesda, MD 20894; Department of Genetics, Washington University School of Medicine, St. Louis, MO 63130; Division of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63130; Department of Molecular Biology and Genetics and McKusick\u2013Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Anthropology, University of Utah, Salt Lake..."}]}],"member":"341","published-online":{"date-parts":[[2002,12,26]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1101\/gr.10.8.1259","volume":"10","author":"Clifford R","year":"2000","unstructured":"R Clifford, M Edmonson, Y Hu, C Nguyen, T Scherpbier, K H Buetow Genome Res 10, 1259\u20131265 (2000).","journal-title":"Genome Res"},{"key":"e_1_3_4_2_2","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/79981","volume":"26","author":"Irizarry K","year":"2000","unstructured":"K Irizarry, V Kustanovich, C Li, N Brown, S Nelson, W Wong, C J Lee Nat Genet 26, 233\u2013236 (2000).","journal-title":"Nat Genet"},{"key":"e_1_3_4_3_2","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/35035083","volume":"407","author":"Altshuler D","year":"2000","unstructured":"D Altshuler, V J Pollara, C R Cowles, W J Van Etten, J Baldwin, L Linton, E S Lander Nature 407, 513\u2013516 (2000).","journal-title":"Nature"},{"key":"e_1_3_4_4_2","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/35035089","volume":"407","author":"Mullikin J C","year":"2000","unstructured":"J C Mullikin, S E Hunt, C G Cole, B J Mortimore, C M Rice, J Burton, L H Matthews, R Pavitt, R W Plumb, S K Sims, et al. Nature 407, 516\u2013520 (2000).","journal-title":"Nature"},{"key":"e_1_3_4_5_2","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1101\/gr.8.7.748","volume":"8","author":"Taillon-Miller P","year":"1998","unstructured":"P Taillon-Miller, Z Gu, Q Li, L Hillier, P Y Kwok Genome Res 8, 748\u2013754 (1998).","journal-title":"Genome Res"},{"key":"e_1_3_4_6_2","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1093\/genetics\/147.4.1977","volume":"147","author":"Sherry S T","year":"1997","unstructured":"S T Sherry, H C Harpending, M A Batzer, M Stoneking Genetics 147, 1977\u20131982 (1997).","journal-title":"Genetics"},{"key":"e_1_3_4_7_2","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/10290","volume":"22","author":"Cargill M","year":"1999","unstructured":"M Cargill, D Altshuler, J Ireland, P Sklar, K Ardlie, N Patil, N Shaw, C R Lane, E P Lim, N Kalyanaraman, et al. Nat Genet 22, 231\u2013238 (1999).","journal-title":"Nat Genet"},{"key":"e_1_3_4_8_2","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0168-9525(00)02058-8","volume":"16","author":"Sunyaev S R","year":"2000","unstructured":"S R Sunyaev, W C Lathe, V E Ramensky, P Bork Trends Genet 16, 335\u2013337 (2000).","journal-title":"Trends Genet"},{"key":"e_1_3_4_9_2","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1146\/annurev.genom.1.1.361","volume":"1","author":"Harpending H","year":"2000","unstructured":"H Harpending, A Rogers Annu Rev Genomics Hum Genet 1, 361\u2013385 (2000).","journal-title":"Annu Rev Genomics Hum Genet"},{"key":"e_1_3_4_10_2","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1093\/bioinformatics\/18.2.337","volume":"18","author":"Hudson R R","year":"2002","unstructured":"R R Hudson Bioinformatics 18, 337\u2013338 (2002).","journal-title":"Bioinformatics"},{"key":"e_1_3_4_11_2","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1089\/10665270050081478","volume":"7","author":"Zhang Z","year":"2000","unstructured":"Z Zhang, S Schwartz, L Wagner, W Miller J Comput Biol 7, 203\u2013214 (2000).","journal-title":"J Comput Biol"},{"key":"e_1_3_4_12_2","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/70570","volume":"23","author":"Marth G T","year":"1999","unstructured":"G T Marth, I Korf, M D Yandell, R T Yeh, Z Gu, H Zakeri, N O Stitziel, L Hillier, P Y Kwok, W R Gish Nat Genet 23, 452\u2013456 (1999).","journal-title":"Nat Genet"},{"key":"e_1_3_4_13_2","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1101\/gr.8.3.195","volume":"8","author":"Gordon D","year":"1998","unstructured":"D Gordon, C Abajian, P Green Genome Res 8, 195\u2013202 (1998).","journal-title":"Genome Res"},{"key":"e_1_3_4_14_2","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/35057062","volume":"409","author":"Lander E S","year":"2001","unstructured":"E S Lander, L M Linton, B Birren, C Nusbaum, M C Zody, J Baldwin, K Devon, K Dewar, M Doyle, W FitzHugh, et al. Nature 409, 860\u2013921 (2001).","journal-title":"Nature"},{"key":"e_1_3_4_15_2","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/86864","volume":"27","author":"Marth G","year":"2001","unstructured":"G Marth, R Yeh, M Minton, R Donaldson, Q Li, S Duan, R Davenport, R D Miller, P Y Kwok Nat Genet 27, 371\u2013372 (2001).","journal-title":"Nat Genet"},{"key":"e_1_3_4_16_2","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1038\/217624a0","volume":"217","author":"Kimura M","year":"1968","unstructured":"M Kimura Nature 217, 624\u2013626 (1968).","journal-title":"Nature"},{"key":"e_1_3_4_17_2","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/0040-5809(75)90020-9","volume":"7","author":"Watterson G A","year":"1975","unstructured":"G A Watterson Theor Popul Biol 7, 256\u2013276 (1975).","journal-title":"Theor Popul Biol"},{"key":"e_1_3_4_18_2","first-page":"1","volume-title":"Oxford Surveys in Evolutionary Biology","author":"Hudson R R","year":"1990","unstructured":"R R Hudson Oxford Surveys in Evolutionary Biology, eds D J Futuyama, J Antonovics (Oxford Univ. Press, Oxford) 7, 1\u201344 (1990)."},{"key":"e_1_3_4_19_2","unstructured":"Kondrashov A. S. (2003) Hum. Mutat. in press."},{"key":"e_1_3_4_20_2","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1093\/genetics\/156.1.297","volume":"156","author":"Nachman M W","year":"2000","unstructured":"M W Nachman, S L Crowell Genetics 156, 297\u2013304 (2000).","journal-title":"Genetics"},{"key":"e_1_3_4_21_2","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1038\/35057185","volume":"409","author":"Yu A","year":"2001","unstructured":"A Yu, C Zhao, Y Fan, W Jang, A J Mungall, P Deloukas, A Olsen, N A Doggett, N Ghebranious, K W Broman, et al. Nature 409, 951\u2013953 (2001).","journal-title":"Nature"},{"key":"e_1_3_4_22_2","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/nature00879","volume":"418","author":"Brunet M","year":"2002","unstructured":"M Brunet, F Guy, D Pilbeam, H T Mackaye, A Likius, D Ahounta, A Beauvilain, C Blondel, H Bocherens, J R Boisserie, et al. Nature 418, 145\u2013151 (2002).","journal-title":"Nature"},{"key":"e_1_3_4_23_2","volume-title":"Analysis of Human Genetic Linkage","author":"Ott J","year":"1991","unstructured":"J Ott Analysis of Human Genetic Linkage (John Hopkins Univ. Press, 2nd Ed., Baltimore, 1991).","edition":"2"},{"key":"e_1_3_4_24_2","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1101\/gr.9.8.677","volume":"9","author":"Sherry S T","year":"1999","unstructured":"S T Sherry, M Ward, K Sirotkin Genome Res 9, 677\u2013679 (1999).","journal-title":"Genome Res"},{"key":"e_1_3_4_25_2","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1038\/35057149","volume":"409","author":"Sachidanandam R","year":"2001","unstructured":"R Sachidanandam, D Weissman, S C Schmidt, J M Kakol, L D Stein, G Marth, S Sherry, J C Mullikin, B J Mortimore, D L Willey, et al. Nature 409, 928\u2013933 (2001).","journal-title":"Nature"},{"key":"e_1_3_4_26_2","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/35075590","volume":"411","author":"Reich D E","year":"2001","unstructured":"D E Reich, M Cargill, S Bolk, J Ireland, P C Sabeti, D J Richter, T Lavery, R Kouyoumjian, S F Farhadian, R Ward, et al. Nature 411, 199\u2013204 (2001).","journal-title":"Nature"},{"key":"e_1_3_4_27_2","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1086\/342727","volume":"71","author":"Weber J L","year":"2002","unstructured":"J L Weber, D David, J Heil, Y Fan, C Zhao, G T Marth Am J Hum Genet 71, 854\u2013862 (2002).","journal-title":"Am J Hum Genet"},{"key":"e_1_3_4_28_2","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1093\/genetics\/148.4.1921","volume":"148","author":"Kimmel M","year":"1998","unstructured":"M Kimmel, R Chakraborty, J P King, M Bamshad, W S Watkins, L B Jorde Genetics 148, 1921\u20131930 (1998).","journal-title":"Genetics"},{"key":"e_1_3_4_29_2","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1093\/oxfordjournals.molbev.a003911","volume":"18","author":"Pereira L","year":"2001","unstructured":"L Pereira, I Dupanloup, Z H Rosser, M A Jobling, G Barbujani Mol Biol Evol 18, 1259\u20131271 (2001).","journal-title":"Mol Biol Evol"},{"key":"e_1_3_4_30_2","doi-asserted-by":"crossref","first-page":"R576","DOI":"10.1016\/S0960-9822(01)00348-7","volume":"11","author":"Goldstein D B","year":"2001","unstructured":"D B Goldstein, M E Weale Curr Biol 11, R576\u2013R579 (2001).","journal-title":"Curr Biol"},{"key":"e_1_3_4_31_2","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1126\/science.1069424","volume":"296","author":"Gabriel S B","year":"2002","unstructured":"S B Gabriel, S F Schaffner, H Nguyen, J M Moore, J Roy, B Blumenstiel, J Higgins, M DeFelice, A Lochner, M Faggart, et al. Science 296, 2225\u20132229 (2002).","journal-title":"Science"},{"key":"e_1_3_4_32_2","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1006\/geno.2000.6417","volume":"71","author":"Miller R D","year":"2001","unstructured":"R D Miller, P Taillon-Miller, P Y Kwok Genomics 71, 78\u201388 (2001).","journal-title":"Genomics"},{"key":"e_1_3_4_33_2","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/ng1001-217","volume":"29","author":"Jeffreys A J","year":"2001","unstructured":"A J Jeffreys, L Kauppi, R Neumann Nat Genet 29, 217\u2013222 (2001).","journal-title":"Nat Genet"},{"key":"e_1_3_4_34_2","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0168-9525(01)02409-X","volume":"17","author":"Nachman M W","year":"2001","unstructured":"M W Nachman Trends Genet 17, 481\u2013485 (2001).","journal-title":"Trends Genet"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.222673099","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T05:59:54Z","timestamp":1654581594000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.222673099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,12,26]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2003,1,7]]}},"alternative-id":["10.1073\/pnas.222673099"],"URL":"https:\/\/doi.org\/10.1073\/pnas.222673099","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,12,26]]},"assertion":[{"value":"2002-11-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2002-12-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}