{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T04:55:51Z","timestamp":1777438551440,"version":"3.51.4"},"reference-count":38,"publisher":"Proceedings of the National Academy of Sciences","issue":"26","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2000,12,19]]},"abstract":"<jats:p>We have identified three C\/D-box small nucleolar RNAs (snoRNAs)\n and one H\/ACA-box snoRNA in mouse and human. In mice, all four\n snoRNAs (MBII-13, MBII-52, MBII-85, and MBI-36) are exclusively\n expressed in the brain, unlike all other known snoRNAs. Two of the\n human RNA orthologues (HBII-52 and HBI-36) share this expression\n pattern, and the remainder, HBII-13 and HBII-85, are prevalently\n expressed in that tissue. In mice and humans, the brain-specific\n H\/ACA box snoRNA (MBI-36 and HBI-36, respectively) is intron-encoded\n in the brain-specific serotonin 2C receptor gene. The three human C\/D\n box snoRNAs map to chromosome 15q11\u2013q13, within a region implicated in\n the Prader\u2013Willi syndrome (PWS), which is a neurogenetic disease\n resulting from a deficiency of paternal gene expression. Unlike other\n C\/D box snoRNAs, two snoRNAs, HBII-52 and HBII-85, are encoded in a\n tandemly repeated array of 47 or 24 units, respectively. In mouse the\n homologue of HBII-52 is processed from intronic portions of the tandem\n repeats. Interestingly, these snoRNAs were absent from the cortex of a\n patient with PWS and from a PWS mouse model, demonstrating their\n paternal imprinting status and pointing to their potential role in the\n etiology of PWS. Despite displaying hallmarks of the two families of\n ubiquitous snoRNAs that guide 2\u2032-O-ribose methylation and\n pseudouridylation of rRNA, respectively, they lack any telltale rRNA\n complementarity. Instead, brain-specific C\/D box snoRNA HBII-52 has\n an 18-nt phylogenetically conserved complementarity to a critical\n segment of serotonin 2C receptor mRNA, pointing to a potential role in\n the processing of this mRNA.<\/jats:p>","DOI":"10.1073\/pnas.250426397","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:44:19Z","timestamp":1027680259000},"page":"14311-14316","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":477,"title":["Identification of brain-specific and imprinted small nucleolar RNA genes exhibiting an unusual genomic organization"],"prefix":"10.1073","volume":"97","author":[{"given":"J\u00e9r\u00f4me","family":"Cavaill\u00e9","sequence":"first","affiliation":[{"name":"Laboratoire de Biologie Mol\u00e9culaire Eukaryote du Centre\r National de la Recherche Scientifique, Universit\u00e9 Paul-Sabatier,\r Toulouse, 31062 France; Institut f\u00fcr\r Humangenetik, Universit\u00e4tsklinikum, Essen, and\r Institute for Experimental Pathology, Zentrum f\u00fcr\r Molekulare Biologie der Entz\u00fcndung, M\u00fcnster, 48149 Germany;\r Department of Genetics and Developmental Biology, School\r of Medicine, University of Connecticut Health Center, Farmington,\r CT 06032; and Department of Molecular Genetics and\r..."}]},{"given":"Karin","family":"Buiting","sequence":"additional","affiliation":[{"name":"Laboratoire de Biologie Mol\u00e9culaire Eukaryote du Centre\r National de la Recherche Scientifique, Universit\u00e9 Paul-Sabatier,\r Toulouse, 31062 France; Institut f\u00fcr\r Humangenetik, Universit\u00e4tsklinikum, Essen, and\r Institute for Experimental Pathology, Zentrum f\u00fcr\r Molekulare Biologie der Entz\u00fcndung, M\u00fcnster, 48149 Germany;\r Department of Genetics and Developmental Biology, School\r of Medicine, University of Connecticut Health Center, Farmington,\r CT 06032; and Department of Molecular Genetics and\r..."}]},{"given":"Martin","family":"Kiefmann","sequence":"additional","affiliation":[{"name":"Laboratoire de Biologie Mol\u00e9culaire Eukaryote du Centre\r National de la Recherche Scientifique, Universit\u00e9 Paul-Sabatier,\r Toulouse, 31062 France; Institut f\u00fcr\r Humangenetik, Universit\u00e4tsklinikum, Essen, and\r Institute for Experimental Pathology, Zentrum f\u00fcr\r Molekulare Biologie der Entz\u00fcndung, M\u00fcnster, 48149 Germany;\r Department of Genetics and Developmental Biology, School\r of Medicine, University of Connecticut Health Center, Farmington,\r CT 06032; and Department of Molecular Genetics and\r..."}]},{"given":"Marc","family":"Lalande","sequence":"additional","affiliation":[{"name":"Laboratoire de Biologie Mol\u00e9culaire Eukaryote du Centre\r National de la Recherche Scientifique, Universit\u00e9 Paul-Sabatier,\r Toulouse, 31062 France; Institut f\u00fcr\r Humangenetik, Universit\u00e4tsklinikum, Essen, and\r Institute for Experimental Pathology, Zentrum f\u00fcr\r Molekulare Biologie der Entz\u00fcndung, M\u00fcnster, 48149 Germany;\r Department of Genetics and Developmental Biology, School\r of Medicine, University of Connecticut Health Center, Farmington,\r CT 06032; and Department of Molecular Genetics and\r..."}]},{"given":"Camilynn I.","family":"Brannan","sequence":"additional","affiliation":[{"name":"Laboratoire de Biologie Mol\u00e9culaire Eukaryote du Centre\r National de la Recherche Scientifique, Universit\u00e9 Paul-Sabatier,\r Toulouse, 31062 France; Institut f\u00fcr\r Humangenetik, Universit\u00e4tsklinikum, Essen, and\r Institute for Experimental Pathology, Zentrum f\u00fcr\r Molekulare Biologie der Entz\u00fcndung, M\u00fcnster, 48149 Germany;\r Department of Genetics and Developmental Biology, School\r of Medicine, University of Connecticut Health Center, Farmington,\r CT 06032; and Department of Molecular Genetics and\r..."}]},{"given":"Bernhard","family":"Horsthemke","sequence":"additional","affiliation":[{"name":"Laboratoire de Biologie Mol\u00e9culaire Eukaryote du Centre\r National de la Recherche Scientifique, Universit\u00e9 Paul-Sabatier,\r Toulouse, 31062 France; Institut f\u00fcr\r Humangenetik, Universit\u00e4tsklinikum, Essen, and\r Institute for Experimental Pathology, Zentrum f\u00fcr\r Molekulare Biologie der Entz\u00fcndung, M\u00fcnster, 48149 Germany;\r Department of Genetics and Developmental Biology, School\r of Medicine, University of Connecticut Health Center, Farmington,\r CT 06032; and Department of Molecular Genetics and\r..."}]},{"given":"Jean-Pierre","family":"Bachellerie","sequence":"additional","affiliation":[{"name":"Laboratoire de Biologie Mol\u00e9culaire Eukaryote du Centre\r National de la Recherche Scientifique, Universit\u00e9 Paul-Sabatier,\r Toulouse, 31062 France; Institut f\u00fcr\r Humangenetik, Universit\u00e4tsklinikum, Essen, and\r Institute for Experimental Pathology, Zentrum f\u00fcr\r Molekulare Biologie der Entz\u00fcndung, M\u00fcnster, 48149 Germany;\r Department of Genetics and Developmental Biology, School\r of Medicine, University of Connecticut Health Center, Farmington,\r CT 06032; and Department of Molecular Genetics and\r..."}]},{"given":"J\u00fcrgen","family":"Brosius","sequence":"additional","affiliation":[{"name":"Laboratoire de Biologie Mol\u00e9culaire Eukaryote du Centre\r National de la Recherche Scientifique, Universit\u00e9 Paul-Sabatier,\r Toulouse, 31062 France; Institut f\u00fcr\r Humangenetik, Universit\u00e4tsklinikum, Essen, and\r Institute for Experimental Pathology, Zentrum f\u00fcr\r Molekulare Biologie der Entz\u00fcndung, M\u00fcnster, 48149 Germany;\r Department of Genetics and Developmental Biology, School\r of Medicine, University of Connecticut Health Center, Farmington,\r CT 06032; and Department of Molecular Genetics and\r..."}]},{"given":"Alexander","family":"H\u00fcttenhofer","sequence":"additional","affiliation":[{"name":"Laboratoire de Biologie Mol\u00e9culaire Eukaryote du Centre\r National de la Recherche Scientifique, Universit\u00e9 Paul-Sabatier,\r Toulouse, 31062 France; Institut f\u00fcr\r Humangenetik, Universit\u00e4tsklinikum, Essen, and\r Institute for Experimental Pathology, Zentrum f\u00fcr\r Molekulare Biologie der Entz\u00fcndung, M\u00fcnster, 48149 Germany;\r Department of Genetics and Developmental Biology, School\r of Medicine, University of Connecticut Health Center, Farmington,\r CT 06032; 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