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LTD, saturated by repeated induction protocols, can be reversed by a single round of postsynaptic LTP or nitric oxide (NO), enabling LTD to be reinduced. Conversely, after postsynaptic LTP has been saturated, one round of LTD permits fresh postsynaptic LTP. By contrast, after saturation of LTD, induction of presynaptic LTP or application of forskolin leaves LTD still saturated. Likewise, presynaptic LTP cannot be reversed by LTD. Therefore postsynaptic LTP mediated by NO without postsynaptic Ca\n            <jats:sup>2+<\/jats:sup>\n            elevation, unlike presynaptic LTP mediated by cAMP, is a true counterbalance to LTD mediated by coincidence of NO plus postsynaptic Ca\n            <jats:sup>2+<\/jats:sup>\n          <\/jats:p>","DOI":"10.1073\/pnas.2636935100","type":"journal-article","created":{"date-parts":[[2003,12,23]],"date-time":"2003-12-23T17:58:11Z","timestamp":1072202291000},"page":"15989-15993","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":149,"title":["Reversing cerebellar long-term depression"],"prefix":"10.1073","volume":"100","author":[{"given":"Varda","family":"Lev-Ram","sequence":"first","affiliation":[{"name":"Departments of Pharmacology and Physics, Graduate Program in Neurosciences, and Howard Hughes Medical Institute, University of California at San Diego, La Jolla, CA 92093-0647"}]},{"given":"Samar B.","family":"Mehta","sequence":"additional","affiliation":[{"name":"Departments of Pharmacology and Physics, Graduate Program in Neurosciences, and Howard Hughes Medical Institute, University of California at San Diego, La Jolla, CA 92093-0647"}]},{"given":"David","family":"Kleinfeld","sequence":"additional","affiliation":[{"name":"Departments of Pharmacology and Physics, Graduate Program in Neurosciences, and Howard Hughes Medical Institute, University of California at San Diego, La Jolla, CA 92093-0647"}]},{"given":"Roger Y.","family":"Tsien","sequence":"additional","affiliation":[{"name":"Departments of Pharmacology and Physics, Graduate Program in Neurosciences, and Howard Hughes Medical Institute, University of California at San Diego, La Jolla, CA 92093-0647"}]}],"member":"341","published-online":{"date-parts":[[2003,12,11]]},"reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80978-2"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81397-5"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.272.5265.1126"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2001.81.3.1143"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1088383"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00562-2"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.130414597"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(95)90044-6"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80340-2"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1080\/147342202753203041"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1993.tb00961.x"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1090462"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80099-9"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-23-10221.1999"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-22-08687.1997"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80500-0"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1998.79.6.3151"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.122206399"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-5193(77)90146-1"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/5.2.95"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1101\/lm.4.1.130"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-21-09112.1998"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(00)00154-9"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)00070-2"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-14-05516.2000"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn1126"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(92)90248-C"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.13-07-02910.1993"},{"key":"e_1_3_2_29_2","first-page":"611","volume":"2","year":"1990","unstructured":"Willshaw, D. 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