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Injected in the neopallium of the golden hamster at the time of production of neurons normally destined for layers IV, III, and II, ibotenate induces arrests of migrating neurons at different distances from the germinative zone within the radial migratory corridors. The resulting cytoarchitectonic patterns include periventricular nodular heterotopias, subcortical band heterotopias, and intracortical arrests of migrating neurons. The radial glial cells and the extracellular matrix are free of detectable damage that could suggest a defect in their guiding role. The migration disorders are prevented by coinjection of<jats:sc>dl<\/jats:sc>-2-amino-7-phosphoheptanoic acid, an NMDA ionotropic antagonist, but are not prevented by coinjection of<jats:sc>l<\/jats:sc>(+)-2-amino-3-phosphonopropionic acid, a metabotropic antagonist. This implies that an excess of ionic influx through the NMDA channels of neurons alters the metabolic pathways supporting neuronal migration. Ibotenate, a unique molecular trigger of the excitotoxic cascade, produces a wide spectrum of abnormal neuronal migration patterns recognized in mammals, including the neocortical deviations encountered in the human brain.<\/jats:p>","DOI":"10.1073\/pnas.93.26.15463","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T14:40:52Z","timestamp":1027694452000},"page":"15463-15468","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":78,"title":["Arrest of neuronal migration by excitatory amino acids in hamster developing\u2009brain"],"prefix":"10.1073","volume":"93","author":[{"given":"St\u00e9phane","family":"Marret","sequence":"first","affiliation":[{"name":"Laboratoire de Neurologie du D\u00e9veloppement and Service de Neurologie P\u00e9diatrique, H\u00f4pital Robert-Debr\u00e9, and Facult\u00e9 de M\u00e9decine Xavier-Bichat, (Universit\u00e9 de Paris VII), 48 Boulevard S\u00e9rurier, F-75019 Paris, 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