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The corresponding gene was assigned to chromosome 14q31, the same region where genetic alterations have been associated with several abnormalities of thyroid hormone response. The protein uses two distinct regions to bind Rb and thyroid hormone receptor (TR), respectively, and thus was named Trip230. Trip230 binds to Rb independently of thyroid hormone while it forms a complex with TR in a thyroid hormone-dependent manner. Ectopic expression of the protein Trip230 in cells, but not a mutant form that does not bind to TR, enhances specifically TR-dependent transcriptional activity. Coexpression of wild-type Rb, but not mutant Rb that fails to bind to Trip230, inhibits such activity. These results not only identify a coactivator molecule that modulates TR activity, but also uncover a role for Rb in a pathway that responds to thyroid hormone.<\/jats:p>","DOI":"10.1073\/pnas.94.17.9040","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T14:42:40Z","timestamp":1027694560000},"page":"9040-9045","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":53,"title":["A thyroid hormone receptor coactivator negatively regulated by the retinoblastoma\u2009protein"],"prefix":"10.1073","volume":"94","author":[{"given":"Kai-Hsuan","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Molecular Medicine and Institute of Biotechnology, University of Texas Health Science Center at San Antonio, 15355 Lambda Drive,  San Antonio, TX 78245; Department of Genetics, Obstetrics, and Gynecology, Yale University School of Medicine, New Haven, CT 06510; and  Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030"}]},{"given":"Yumay","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Institute of Biotechnology, University of Texas Health Science Center at San Antonio, 15355 Lambda Drive,  San Antonio, TX 78245; Department of Genetics, Obstetrics, and Gynecology, Yale University School of Medicine, New Haven, CT 06510; and  Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030"}]},{"given":"Tung-Ti","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Institute of Biotechnology, University of Texas Health Science Center at San Antonio, 15355 Lambda Drive,  San Antonio, TX 78245; Department of Genetics, Obstetrics, and Gynecology, Yale University School of Medicine, New Haven, CT 06510; and  Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030"}]},{"given":"Wen-Hai","family":"Chou","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Institute of Biotechnology, University of Texas Health Science Center at San Antonio, 15355 Lambda Drive,  San Antonio, TX 78245; Department of Genetics, Obstetrics, and Gynecology, Yale University School of Medicine, New Haven, CT 06510; and  Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030"}]},{"given":"Phang-Lang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Institute of Biotechnology, University of Texas Health Science Center at San Antonio, 15355 Lambda Drive,  San Antonio, TX 78245; Department of Genetics, Obstetrics, and Gynecology, Yale University School of Medicine, New Haven, CT 06510; and  Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030"}]},{"given":"Yen-Ying","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Institute of Biotechnology, University of Texas Health Science Center at San Antonio, 15355 Lambda Drive,  San Antonio, TX 78245; Department of Genetics, Obstetrics, and Gynecology, Yale University School of Medicine, New Haven, CT 06510; and  Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030"}]},{"given":"Teresa L.","family":"Yang-Feng","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Institute of Biotechnology, University of Texas Health Science Center at San Antonio, 15355 Lambda Drive,  San Antonio, TX 78245; Department of Genetics, Obstetrics, and Gynecology, Yale University School of Medicine, New Haven, CT 06510; and  Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030"}]},{"given":"Xiaohua","family":"Leng","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Institute of Biotechnology, University of Texas Health Science Center at San Antonio, 15355 Lambda Drive,  San Antonio, TX 78245; Department of Genetics, Obstetrics, and Gynecology, Yale University School of Medicine, New Haven, CT 06510; and  Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030"}]},{"given":"Ming-Jer","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Institute of Biotechnology, University of Texas Health Science Center at San Antonio, 15355 Lambda Drive,  San Antonio, TX 78245; Department of Genetics, Obstetrics, and Gynecology, Yale University School of Medicine, New Haven, CT 06510; and  Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030"}]},{"given":"Bert W.","family":"O\u2019Malley","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Institute of Biotechnology, University of Texas Health Science Center at San Antonio, 15355 Lambda Drive,  San Antonio, TX 78245; Department of Genetics, Obstetrics, and Gynecology, Yale University School of Medicine, New Haven, CT 06510; and  Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030"}]},{"given":"Wen-Hwa","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Institute of Biotechnology, University of Texas Health Science Center at San Antonio, 15355 Lambda Drive,  San Antonio, TX 78245; Department of Genetics, Obstetrics, and Gynecology, Yale University School of Medicine, New Haven, CT 06510; and  Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030"}]}],"member":"341","published-online":{"date-parts":[[1997,8,19]]},"reference":[{"key":"e_1_3_4_1_2","first-page":"43","volume":"1155","author":"Goodrich D W","year":"1993","unstructured":"D W Goodrich, W H Lee Biochim Biophys Acta 1155, 43\u201361 (1993).","journal-title":"Biochim Biophys Acta"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cb.10.110194.000245"},{"key":"e_1_3_4_3_2","first-page":"211","volume":"2","author":"Bookstein R","year":"1991","unstructured":"R Bookstein, W H Lee Crit Rev Oncog 2, 211\u2013227 (1991).","journal-title":"Crit Rev Oncog"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3823889"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90508-4"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90517-5"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90507-2"},{"key":"e_1_3_4_8_2","first-page":"79","volume":"5","author":"Chen P L","year":"1995","unstructured":"P L Chen, D J Riley, W H Lee Crit Rev Eukaryotic Gene Expression 5, 79\u201395 (1995).","journal-title":"Crit Rev Eukaryotic Gene Expression"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90181-W"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90249-C"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.7.9.1654"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/359328a0"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/359295a0"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/359288a0"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90110-C"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.1.465"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.10.21.2794"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1411535"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.12.12.5620-5631.1992"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90214-W"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.13.10.6501-6508.1993"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1101\/SQB.1994.059.01.013"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.7.4.555"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90202-3"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90201-5"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.63.070194.002315"},{"key":"e_1_3_4_27_2","first-page":"184","volume":"14","author":"Lazar M A","year":"1993","unstructured":"M A Lazar Endocr Rev 14, 184\u2013193 (1993).","journal-title":"Endocr Rev"},{"key":"e_1_3_4_28_2","first-page":"157","volume":"1032","author":"Glass C K","year":"1990","unstructured":"C K Glass, J M Holloway Biochim Biophys Acta 1032, 157\u2013176 (1990).","journal-title":"Biochim Biophys Acta"},{"key":"e_1_3_4_29_2","first-page":"1117","volume":"37","author":"Yang-Feng T L","year":"1985","unstructured":"T L Yang-Feng, G Floyd-Smith, M Nemer, J Drouin, U Francke Am J Hum Genet 37, 1117\u20131128 (1985).","journal-title":"Am J Hum Genet"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)31713-7"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(88)90403-9"},{"key":"e_1_3_4_32_2","first-page":"2232","volume-title":"Mendelian Inheritance in Man","author":"Mckusick V A","year":"1994","unstructured":"V A Mckusick Mendelian Inheritance in Man (Johns Hopkins Univ. 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