{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T06:23:32Z","timestamp":1779344612695,"version":"3.51.4"},"reference-count":73,"publisher":"Proceedings of the National Academy of Sciences","issue":"14","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1998,7,7]]},"abstract":"<jats:p>\n            Hairpin structures can inhibit DNA replication and are intermediates in certain recombination reactions. We have shown that the purified SbcCD protein of\n            <jats:italic>Escherichia coli<\/jats:italic>\n            cleaves a DNA hairpin. This cleavage does not require the presence of a free (3\u2032 or 5\u2032) DNA end and generates products with 3\u2032-hydroxyl and 5\u2032-phosphate termini. Electron microscopy of SbcCD has revealed the \u201chead-rod-tail\u201d structure predicted for the SMC (structural maintenance of chromosomes) family of proteins, of which SbcC is a member. This work provides evidence consistent with the proposal that SbcCD cleaves hairpin structures that halt the progress of the replication fork, allowing homologous recombination to restore DNA replication.\n          <\/jats:p>","DOI":"10.1073\/pnas.95.14.7969","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T14:39:15Z","timestamp":1027694355000},"page":"7969-7974","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":191,"title":["The SbcCD nuclease of\n            <i>Escherichia coli<\/i>\n            is a structural maintenance of chromosomes (SMC) family protein that cleaves hairpin DNA"],"prefix":"10.1073","volume":"95","author":[{"given":"John C.","family":"Connelly","sequence":"first","affiliation":[{"name":"Institute of Cell and Molecular Biology, University of Edinburgh, Kings Buildings, Edinburgh EH9 3JR, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucy A.","family":"Kirkham","sequence":"additional","affiliation":[{"name":"Institute of Cell and Molecular Biology, University of Edinburgh, Kings Buildings, Edinburgh EH9 3JR, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David R. 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