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In addition, although the inhibition of cyclin E\/cdk2 activity blocks the induction of S phase after growth stimulation of normal mouse embryo fibroblasts, inhibition of cyclin E\/cdk2 does not block S phase induction in Rb\u2212\/\u2212 cells where E2F activity is deregulated. These results point to the important roles for E2F and cyclin E\/cdk2 in the induction of S phase. Moreover, the nature of the E2F targets and the suspected targets for cyclin E\/cdk2 suggests a potential molecular mechanism for the collaborative action of cyclin E\/cdk2 and E2F in the induction of S phase.<\/jats:p>","DOI":"10.1073\/pnas.96.12.6626","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T14:32:33Z","timestamp":1027693953000},"page":"6626-6631","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":56,"title":["Collaborative role of E2F transcriptional activity and G\n            <sub>1<\/sub>\n            cyclindependent kinase activity in the induction of S phase"],"prefix":"10.1073","volume":"96","author":[{"given":"Gustavo","family":"Leone","sequence":"first","affiliation":[{"name":"Department of Genetics, Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 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