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Surprisingly, we found that even the most conventional measures of receptive field (RF) size were not fixed, but could vary depending on stimulus contrast and foreground\u2013background relationships. On average, the length of the excitatory RF was 4-fold greater for a low-contrast stimulus than for a stimulus at high contrast. Embedding a high-contrast stimulus in a textured background tended to suppress neuronal responses and produced an enlargement in RF size similar to that observed by decreasing the contrast of an isolated stimulus. The results show that RF dimensions are regulated in a dynamic manner that depends both on local stimulus characteristics, such as contrast, and on global relationships between a stimulus and its surroundings.<\/jats:p>","DOI":"10.1073\/pnas.96.21.12073","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T14:41:48Z","timestamp":1027694508000},"page":"12073-12078","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":235,"title":["Dynamics of spatial summation in primary visual cortex of alert monkeys"],"prefix":"10.1073","volume":"96","author":[{"given":"Mitesh K.","family":"Kapadia","sequence":"first","affiliation":[{"name":"The Rockefeller University, New York, NY 10021; and Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104"}]},{"given":"Gerald","family":"Westheimer","sequence":"additional","affiliation":[{"name":"The Rockefeller University, New York, 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