{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:12:33Z","timestamp":1791263553504,"version":"4.1.0"},"reference-count":38,"publisher":"National Academy of Sciences","issue":"26","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2001,12,18]]},"abstract":"<jats:p>\n                    Autologous serum antibodies to molecules that are aberrantly\n expressed in tumors represent potential biomarkers for early diagnosis\n of cancer. In this study, we identified the homeobox gene\n                    <jats:italic>HOXA7<\/jats:italic>\n                    as encoding an antigen in epithelial tumors of the\n ovary. These tumors are thought to arise from the simple epithelium\n lining the ovarian surface, but they often resemble the specialized\n epithelia derived from the m\u00fcllerian ducts. Expression of HOXA7\n was detected in ovarian tumors exhibiting m\u00fcllerian-like features\n and correlated with the generation of anti-HOXA7 antibodies by\n patients. In contrast, it was observed that healthy women lack\n anti-HOXA7 antibodies (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.0001) and that HOXA7\n expression is absent from normal ovarian surface epithelium.\n Interestingly, HOXA7 expression was detected in the\n m\u00fcllerian-like epithelium lining inclusion cysts in normal\n ovaries and in the m\u00fcllerian duct-derived epithelium of normal\n fallopian tubes. Furthermore, ectopic expression of\n                    <jats:italic>HOXA7<\/jats:italic>\n                    enhanced the epithelial phenotype of immortalized\n ovarian surface epithelial cells, as indicated by the appearance of\n cobblestone morphology, induction of E-cadherin expression, and\n down-regulation of vimentin. These findings associate aberrant\n                    <jats:italic>HOXA7<\/jats:italic>\n                    expression with the m\u00fcllerian-like\n differentiation of epithelial ovarian tumors and suggest diagnostic\n utility of serum antibodies to HOXA7.\n                  <\/jats:p>","DOI":"10.1073\/pnas.011503998","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:36:44Z","timestamp":1027679804000},"page":"15209-15214","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":76,"title":["Aberrant expression of homeobox gene\n                    <i>HOXA7<\/i>\n                    is associated with m\u00fcllerian-like differentiation of epithelial ovarian tumors and the generation of a specific autologous antibody response"],"prefix":"10.1073","volume":"98","author":[{"given":"Honami","family":"Naora","sequence":"first","affiliation":[{"name":"Departments of Pathology and Gynecology and\r Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD\r 21205"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredrick J.","family":"Montz","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Gynecology and\r Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD\r 21205"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chee-Yin","family":"Chai","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Gynecology and\r Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD\r 21205"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard B. 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