{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:22:29Z","timestamp":1791404549343,"version":"4.3.3"},"reference-count":43,"publisher":"National Academy of Sciences","issue":"3","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2002,2,5]]},"abstract":"<jats:p>\n                    Plasma cell neoplasms in humans comprise plasma cell myeloma, otherwise known as multiple myeloma, Ig deposition and heavy chain diseases, and plasmacytoma (PCT). A subset of PCT, designated extramedullary PCT, is distinguished from multiple myeloma and solitary PCT of bone by its distribution among various tissue sites but not the bone marrow. Extramedullary (extraosseus) PCT are rare spontaneous neoplasms of mice but are readily induced in a susceptible strain, BALB\/c, by treatment with pristane. The tumors develop in peritoneal granulomas and are characterized by\n                    <jats:italic>Myc<\/jats:italic>\n                    -activating T(12;15) chromosomal translocations and, most frequently, by secretion of IgA. A uniting feature of human and mouse plasma cell neoplasms is the critical role played by IL-6, a B cell growth, differentiation, and survival factor. To directly test the contribution of IL-6 to PCT development, we generated BALB\/c mice carrying a widely expressed IL-6 transgene. All mice exhibited lymphoproliferation and plasmacytosis. By 18 months of age, over half developed readily transplantable PCT in lymph nodes, Peyer's patches, and sometimes spleen. These neoplasms also had T(12;15) translocations, but remarkably, none expressed IgA. Unexpectedly, \u224830% of the mice developed follicular and diffuse large cell B cell lymphomas that often coexisted with PCT. These findings provide a unique model of extramedullary PCT for studies on pathogenesis and treatment and suggest a previously unappreciated role for IL-6 in the genesis of germinal center-derived lymphomas.\n                  <\/jats:p>","DOI":"10.1073\/pnas.022643999","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:36:44Z","timestamp":1027679804000},"page":"1509-1514","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":113,"title":["IL-6 transgenic mouse model for extraosseous plasmacytoma"],"prefix":"10.1073","volume":"99","author":[{"given":"Alexander L.","family":"Kovalchuk","sequence":"first","affiliation":[{"name":"Laboratory of Genetics, Center for Cancer Research, National Cancer Institute, and Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; Korea Research Institute of Bioscience and Biotechnology, Taejon 305-333, Korea; Veterinary and Tumor Pathology Section, National Cancer Institute, National Institutes of Health, Frederick, MD 21702; and Institute for Molecular and Cellular Biology, Osaka University Medical School,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joong Su","family":"Kim","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics, Center for Cancer Research, National Cancer Institute, and Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; Korea Research Institute of Bioscience and Biotechnology, Taejon 305-333, Korea; Veterinary and Tumor Pathology Section, National Cancer Institute, National Institutes of Health, Frederick, MD 21702; and Institute for Molecular and Cellular Biology, Osaka University Medical School,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Sup","family":"Park","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics, Center for Cancer Research, National Cancer Institute, and Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; Korea Research Institute of Bioscience and Biotechnology, Taejon 305-333, Korea; Veterinary and Tumor Pathology Section, National Cancer Institute, National Institutes of Health, Frederick, MD 21702; and Institute for Molecular and Cellular Biology, Osaka University Medical School,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen E.","family":"Coleman","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics, Center for Cancer Research, National Cancer Institute, and Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; Korea Research Institute of Bioscience and Biotechnology, Taejon 305-333, Korea; Veterinary and Tumor Pathology Section, National Cancer Institute, National Institutes of Health, Frederick, MD 21702; and Institute for Molecular and Cellular Biology, Osaka University Medical School,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerrold M.","family":"Ward","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics, Center for Cancer Research, National Cancer Institute, and Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; Korea Research Institute of Bioscience and Biotechnology, Taejon 305-333, Korea; Veterinary and Tumor Pathology Section, National Cancer Institute, National Institutes of Health, Frederick, MD 21702; and Institute for Molecular and Cellular Biology, Osaka University Medical School,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Herbert C.","family":"Morse","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics, Center for Cancer Research, National Cancer Institute, and Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; Korea Research Institute of Bioscience and Biotechnology, Taejon 305-333, Korea; Veterinary and Tumor Pathology Section, National Cancer Institute, National Institutes of Health, Frederick, MD 21702; and Institute for Molecular and Cellular Biology, Osaka University Medical School,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadamitsu","family":"Kishimoto","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics, Center for Cancer Research, National Cancer Institute, and Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; Korea Research Institute of Bioscience and Biotechnology, Taejon 305-333, Korea; Veterinary and Tumor Pathology Section, National Cancer Institute, National Institutes of Health, Frederick, MD 21702; and Institute for Molecular and Cellular Biology, Osaka University Medical School,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Potter","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics, Center for Cancer Research, National Cancer Institute, and Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; Korea Research Institute of Bioscience and Biotechnology, Taejon 305-333, Korea; Veterinary and Tumor Pathology Section, National Cancer Institute, National Institutes of Health, Frederick, MD 21702; and Institute for Molecular and Cellular Biology, Osaka University Medical 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