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Surprisingly, these Abs also bind to other disease-related amyloid fibrils and amyloid-like aggregates derived from other proteins of unrelated sequence, such as transthyretin, islet amyloid polypeptide, \u03b2\n                    <jats:sub>2<\/jats:sub>\n                    -microglobulin, and polyglutamine. At the same time, WO1 and WO2 do not bind to the native protein precursors of these amyloids, nor do they bind to other kinds of protein aggregates. This new class of Abs associated with a fundamental amyloid-folding motif appear to recognize a common conformational epitope with little apparent dependence on amino acid side chain information. These Abs should contribute to the understanding of amyloid structure, assembly, and toxicity and also may benefit the development of diagnostic and therapeutic agents for amyloid diseases.\n                  <\/jats:p>","DOI":"10.1073\/pnas.022662599","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:36:44Z","timestamp":1027679804000},"page":"1485-1490","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":275,"title":["Conformational Abs recognizing a generic amyloid fibril epitope"],"prefix":"10.1073","volume":"99","author":[{"given":"Brian","family":"O'Nuallain","sequence":"first","affiliation":[{"name":"Graduate School of Medicine, University of Tennessee Medical Center, 1924 Alcoa Highway, Knoxville, TN 37920"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Wetzel","sequence":"additional","affiliation":[{"name":"Graduate School of Medicine, University of Tennessee Medical Center, 1924 Alcoa Highway, Knoxville, TN 37920"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2002,1,29]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199709253371306"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199906243402507"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5300.630"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.48.2.241"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.61.070192.004503"},{"key":"e_1_3_3_6_2","first-page":"820","volume-title":"Methods in Enzymology","author":"Wetzel R","year":"1999","unstructured":"R Wetzel Methods in Enzymology, eds J N Abelson, M I Simon (Academic, San Diego), pp. 820 (1999)."},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(01)01951-6"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi010805z"},{"key":"e_1_3_3_9_2","doi-asserted-by":"crossref","first-page":"10","DOI":"10.4049\/jimmunol.111.1.10","volume":"111","author":"Linke R P","year":"1973","unstructured":"R P Linke, D Zucker-Franklin, E C Franklin J Immunol 111, 10\u201323 (1973).","journal-title":"J Immunol"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.6.3108"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/36337"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(99)09003-5"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64639-1"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/22124"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/78682"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/35089090"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.8.4109"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.1.452"},{"key":"e_1_3_3_19_2","first-page":"87","volume":"10","author":"O'Nuallain B","year":"2001","unstructured":"B O'Nuallain, R Wetzel Protein Sci 10, 87\u201388 (2001).","journal-title":"Protein Sci"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.250288897"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(99)09020-5"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1110\/ps.42301"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00151a036"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi000276j"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.2000.3862"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.2001.4850"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(89)90046-8"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)85802-7"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)81724-6"},{"key":"e_1_3_3_30_2","volume-title":"Antibodies: A Laboratory Manual","author":"Harlow E","year":"1988","unstructured":"E Harlow, D Lane Antibodies: A Laboratory Manual (Cold Spring Harbor Lab. 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