{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:50:26Z","timestamp":1781106626697,"version":"3.54.1"},"reference-count":45,"publisher":"National Academy of Sciences","issue":"2","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2003,1,21]]},"abstract":"<jats:p>\n                    UV light provokes DNA lesions that interfere with replication and transcription. These lesions may compromise cell viability and usually are removed by nucleotide excision repair (NER). In humans, inactivation of NER is associated with three rare autosomal recessive inherited disorders: xeroderma pigmentosum (XP), Cockayne syndrome, and trichothiodystrophy. The NER earliest step is lesion recognition by a complex formed by XPC and HHR23B proteins. In a subsequent step, XPA protein becomes associated to the repair complex. Here we investigate whether XPA and XPC proteins, involved in global genome repair, may contribute to a signal transduction pathway regulating the response to UVC-induced lesions. We monitored the expression of several UVC-induced genes in cells deficient in either a transduction pathway or mutated on an NER gene. Expression of the\n                    <jats:italic>KIN17<\/jats:italic>\n                    gene is induced after UVC irradiation independently of p53 and of activating transcription factor 2. However, in human cells derived from XPA or XPC patients the UVC-induced accumulation of\n                    <jats:italic>KIN17<\/jats:italic>\n                    RNA and protein is abolished. Our results indicate that the presence of functional XPA and XPC proteins is essential for the up-regulation of the\n                    <jats:italic>KIN17<\/jats:italic>\n                    gene after UVC irradiation. They also show that the integrity of global genome repair is required to trigger\n                    <jats:italic>KIN17<\/jats:italic>\n                    gene expression and probably other UVC-responsive genes.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0236176100","type":"journal-article","created":{"date-parts":[[2003,1,21]],"date-time":"2003-01-21T17:51:47Z","timestamp":1043171507000},"page":"616-621","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":47,"title":["Global genome repair is required to activate\n                    <i>KIN17<\/i>\n                    , a UVC-responsive gene involved in DNA replication"],"prefix":"10.1073","volume":"100","author":[{"given":"Christel","family":"Masson","sequence":"first","affiliation":[{"name":"Laboratoire de G\u00e9n\u00e9tique de la Radiosensibilit\u00e9, D\u00e9partement de Radiobiologie et de Radiopathologie (DRR), Direction des Sciences du Vivant (DSV), Commissariat \u00e0 l'Energie Atomique (CEA), B.P. 6, 92265 Fontenay aux Roses, France; Laboratoire de Radiobiologie de l'ADN, DRR, DSV, CEA, UMR217 Centre National de la Recherche Scientifique (CNRS)-CEA, Radiobiologie Mol\u00e9culaire et Cellulaire, B.P. 6, 92265 Fontenay aux Roses, France; Service de Pharmacologie et d'Immunologie, D\u00e9partement de Recherche..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farid","family":"Menaa","sequence":"additional","affiliation":[{"name":"Laboratoire de G\u00e9n\u00e9tique de la Radiosensibilit\u00e9, D\u00e9partement de Radiobiologie et de Radiopathologie (DRR), Direction des Sciences du Vivant (DSV), Commissariat \u00e0 l'Energie Atomique (CEA), B.P. 6, 92265 Fontenay aux Roses, France; Laboratoire de Radiobiologie de l'ADN, DRR, DSV, CEA, UMR217 Centre National de la Recherche Scientifique (CNRS)-CEA, Radiobiologie Mol\u00e9culaire et Cellulaire, B.P. 6, 92265 Fontenay aux Roses, France; Service de Pharmacologie et d'Immunologie, D\u00e9partement de Recherche..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghislaine","family":"Pinon-Lataillade","sequence":"additional","affiliation":[{"name":"Laboratoire de G\u00e9n\u00e9tique de la Radiosensibilit\u00e9, D\u00e9partement de Radiobiologie et de Radiopathologie (DRR), Direction des Sciences du Vivant (DSV), Commissariat \u00e0 l'Energie Atomique (CEA), B.P. 6, 92265 Fontenay aux Roses, France; Laboratoire de Radiobiologie de l'ADN, DRR, DSV, CEA, UMR217 Centre National de la Recherche Scientifique (CNRS)-CEA, Radiobiologie Mol\u00e9culaire et Cellulaire, B.P. 6, 92265 Fontenay aux Roses, France; Service de Pharmacologie et d'Immunologie, D\u00e9partement de Recherche..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yveline","family":"Frobert","sequence":"additional","affiliation":[{"name":"Laboratoire de G\u00e9n\u00e9tique de la Radiosensibilit\u00e9, D\u00e9partement de Radiobiologie et de Radiopathologie (DRR), Direction des Sciences du Vivant (DSV), Commissariat \u00e0 l'Energie Atomique (CEA), B.P. 6, 92265 Fontenay aux Roses, France; Laboratoire de Radiobiologie de l'ADN, DRR, DSV, CEA, UMR217 Centre National de la Recherche Scientifique (CNRS)-CEA, Radiobiologie Mol\u00e9culaire et Cellulaire, B.P. 6, 92265 Fontenay aux Roses, France; Service de Pharmacologie et d'Immunologie, D\u00e9partement de Recherche..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Chevillard","sequence":"additional","affiliation":[{"name":"Laboratoire de G\u00e9n\u00e9tique de la Radiosensibilit\u00e9, D\u00e9partement de Radiobiologie et de Radiopathologie (DRR), Direction des Sciences du Vivant (DSV), Commissariat \u00e0 l'Energie Atomique (CEA), B.P. 6, 92265 Fontenay aux Roses, France; Laboratoire de Radiobiologie de l'ADN, DRR, DSV, CEA, UMR217 Centre National de la Recherche Scientifique (CNRS)-CEA, Radiobiologie Mol\u00e9culaire et Cellulaire, B.P. 6, 92265 Fontenay aux Roses, France; Service de Pharmacologie et d'Immunologie, D\u00e9partement de Recherche..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Pablo","family":"Radicella","sequence":"additional","affiliation":[{"name":"Laboratoire de G\u00e9n\u00e9tique de la Radiosensibilit\u00e9, D\u00e9partement de Radiobiologie et de Radiopathologie (DRR), Direction des Sciences du Vivant (DSV), Commissariat \u00e0 l'Energie Atomique (CEA), B.P. 6, 92265 Fontenay aux Roses, France; Laboratoire de Radiobiologie de l'ADN, DRR, DSV, CEA, UMR217 Centre National de la Recherche Scientifique (CNRS)-CEA, Radiobiologie Mol\u00e9culaire et Cellulaire, B.P. 6, 92265 Fontenay aux Roses, France; Service de Pharmacologie et d'Immunologie, D\u00e9partement de Recherche..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Sarasin","sequence":"additional","affiliation":[{"name":"Laboratoire de G\u00e9n\u00e9tique de la Radiosensibilit\u00e9, D\u00e9partement de Radiobiologie et de Radiopathologie (DRR), Direction des Sciences du Vivant (DSV), Commissariat \u00e0 l'Energie Atomique (CEA), B.P. 6, 92265 Fontenay aux Roses, France; Laboratoire de Radiobiologie de l'ADN, DRR, DSV, CEA, UMR217 Centre National de la Recherche Scientifique (CNRS)-CEA, Radiobiologie Mol\u00e9culaire et Cellulaire, B.P. 6, 92265 Fontenay aux Roses, France; Service de Pharmacologie et d'Immunologie, D\u00e9partement de Recherche..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime F.","family":"Angulo","sequence":"additional","affiliation":[{"name":"Laboratoire de G\u00e9n\u00e9tique de la Radiosensibilit\u00e9, D\u00e9partement de Radiobiologie et de Radiopathologie (DRR), Direction des Sciences du Vivant (DSV), Commissariat \u00e0 l'Energie Atomique (CEA), B.P. 6, 92265 Fontenay aux Roses, France; Laboratoire de Radiobiologie de l'ADN, DRR, DSV, CEA, UMR217 Centre National de la Recherche Scientifique (CNRS)-CEA, Radiobiologie Mol\u00e9culaire et Cellulaire, B.P. 6, 92265 Fontenay aux Roses, France; Service de Pharmacologie et d'Immunologie, D\u00e9partement de Recherche..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2003,1,13]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)80132-X"},{"key":"e_1_3_3_2_2","volume-title":"DNA Repair and Mutagenesis","author":"Friedberg E C","year":"1995","unstructured":"E C Friedberg, G C Walker, W Siede DNA Repair and Mutagenesis (Am. 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