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TgK21\n                    <jats:italic>fib<\/jats:italic>\n                    <jats:sup>-\/-<\/jats:sup>\n                    mice had decreased inflammation and expression of major histocompatibility complex class I antigens, reduced demyelination, and a lengthened lifespan compared with TgK21 mice. In a pharmacologic analysis, fibrin depletion, by using the snake venom ancrod, in Tg6074 mice also delayed the onset of inflammatory demyelination. Overall, these results indicate that fibrin regulates the inflammatory response in neuroinflammatory diseases. Design of therapeutic strategies based on fibrin depletion could potentially benefit the clinical course of demyelinating diseases such as multiple sclerosis.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0303859101","type":"journal-article","created":{"date-parts":[[2004,4,19]],"date-time":"2004-04-19T20:56:12Z","timestamp":1082408172000},"page":"6698-6703","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":119,"title":["Fibrin depletion decreases inflammation and delays the onset of demyelination in a tumor necrosis factor transgenic mouse model for multiple sclerosis"],"prefix":"10.1073","volume":"101","author":[{"given":"Katerina","family":"Akassoglou","sequence":"first","affiliation":[{"name":"Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093-0636; Laboratory of Neurobiology and Genetics, The Rockefeller University, New York, NY 10021; Laboratory of Experimental Neuropathology, University of Vienna, A-1090 Vienna, Austria; 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