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We show that torsinA is also present in the nuclear envelope (NE), where it appears to interact with substrate, and that the \u0394E302\/3 mutation causes a striking redistribution of torsinA from the endoplasmic reticulum to the NE. In addition, \u0394E302\/3-torsinA recruits WT torsinA to the NE, potentially providing insight into an understanding of the dominant inheritance of the disease. DYT1 dystonia appears to be a previously uncharacterized NE disease and the first, to our knowledge, to selectively affect CNS function.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0304375101","type":"journal-article","created":{"date-parts":[[2004,1,20]],"date-time":"2004-01-20T12:54:00Z","timestamp":1074603240000},"page":"847-852","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":242,"title":["Mislocalization to the nuclear envelope: An effect of the dystonia-causing torsinA mutation"],"prefix":"10.1073","volume":"101","author":[{"given":"Rose E.","family":"Goodchild","sequence":"first","affiliation":[{"name":"Departments of Neurology and Pharmacology, Columbia University, New York, NY 10032"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William T.","family":"Dauer","sequence":"additional","affiliation":[{"name":"Departments of Neurology and Pharmacology, Columbia University, New York, NY 10032"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2004,1,7]]},"reference":[{"key":"e_1_3_2_1_2","unstructured":"Fahn S. 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