{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:56:58Z","timestamp":1791143818471,"version":"4.1.0"},"reference-count":26,"publisher":"National Academy of Sciences","issue":"9","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2004,3,2]]},"abstract":"<jats:p>\n                    Impaired magnesium reabsorption in patients with\n                    <jats:italic>TRPM6<\/jats:italic>\n                    gene mutations stresses an important role of TRPM6 (melastatin-related TRP cation channel) in epithelial magnesium transport. While attempting to isolate full-length TRPM6, we found that the human\n                    <jats:italic>TRPM6<\/jats:italic>\n                    gene encodes multiple mRNA isoforms. Full-length TRPM6 variants failed to form functional channel complexes because they were retained intracellularly on heterologous expression in HEK 293 cells and\n                    <jats:italic>Xenopus<\/jats:italic>\n                    oocytes. However, TRPM6 specifically interacted with its closest homolog, the Mg\n                    <jats:sup>2+<\/jats:sup>\n                    -permeable cation channel TRPM7, resulting in the assembly of functional TRPM6\/TRPM7 complexes at the cell surface. The naturally occurring S141L TRPM6 missense mutation abrogated the oligomeric assembly of TRPM6, thus providing a cell biological explanation for the human disease. Together, our data suggest an important contribution of TRPM6\/TRPM7 heterooligomerization for the biological role of TRPM6 in epithelial magnesium absorption.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0305252101","type":"journal-article","created":{"date-parts":[[2004,3,2]],"date-time":"2004-03-02T21:33:11Z","timestamp":1078263191000},"page":"2894-2899","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":328,"title":["Disruption of TRPM6\/TRPM7 complex formation by a mutation in the\n                    <i>TRPM6<\/i>\n                    gene causes hypomagnesemia with secondary hypocalcemia"],"prefix":"10.1073","volume":"101","author":[{"given":"Vladimir","family":"Chubanov","sequence":"first","affiliation":[{"name":"Institute for Pharmacology and Toxicology, Philipps University Marburg, 35033 Marburg, Germany; University Children's Hospital, Philipps University Marburg, 35037 Marburg, Germany; and Department of Physiology I, University of Regensburg, 93040 Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siegfried","family":"Waldegger","sequence":"additional","affiliation":[{"name":"Institute for Pharmacology and Toxicology, Philipps University Marburg, 35033 Marburg, Germany; University Children's Hospital, Philipps University Marburg, 35037 Marburg, Germany; and Department of Physiology I, University of Regensburg, 93040 Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael Mederos y","family":"Schnitzler","sequence":"additional","affiliation":[{"name":"Institute for Pharmacology and Toxicology, Philipps University Marburg, 35033 Marburg, Germany; University Children's Hospital, Philipps University Marburg, 35037 Marburg, Germany; and Department of Physiology I, University of Regensburg, 93040 Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helga","family":"Vitzthum","sequence":"additional","affiliation":[{"name":"Institute for Pharmacology and Toxicology, Philipps University Marburg, 35033 Marburg, Germany; University Children's Hospital, Philipps University Marburg, 35037 Marburg, Germany; and Department of Physiology I, University of Regensburg, 93040 Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin C.","family":"Sassen","sequence":"additional","affiliation":[{"name":"Institute for Pharmacology and Toxicology, Philipps University Marburg, 35033 Marburg, Germany; University Children's Hospital, Philipps University Marburg, 35037 Marburg, Germany; and Department of Physiology I, University of Regensburg, 93040 Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannsj\u00f6rg W.","family":"Seyberth","sequence":"additional","affiliation":[{"name":"Institute for Pharmacology and Toxicology, Philipps University Marburg, 35033 Marburg, Germany; University Children's Hospital, Philipps University Marburg, 35037 Marburg, Germany; and Department of Physiology I, University of Regensburg, 93040 Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Konrad","sequence":"additional","affiliation":[{"name":"Institute for Pharmacology and Toxicology, Philipps University Marburg, 35033 Marburg, Germany; University Children's Hospital, Philipps University Marburg, 35037 Marburg, Germany; and Department of Physiology I, University of Regensburg, 93040 Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Gudermann","sequence":"additional","affiliation":[{"name":"Institute for Pharmacology and Toxicology, Philipps University Marburg, 35033 Marburg, Germany; 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