{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T16:05:14Z","timestamp":1781107514240,"version":"3.54.1"},"reference-count":38,"publisher":"National Academy of Sciences","issue":"17","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2004,4,27]]},"abstract":"<jats:p>\n                    Adipocyte-specific secretory factor (ADSF)\/resistin is a small cysteine-rich protein secreted from adipose tissue that belongs to a gene family found in inflammatory zone (FIZZ) or found in resistin-like molecule (RELM). ADSF has been implicated in modulating adipogenesis and insulin resistance. To examine the long-term function of ADSF in adipogenesis and glucose homeostasis, we constructed an expression vector for a dominant inhibitory form of ADSF by fusing it to the human IgG\u03b3 constant region (hFc). ADSF-hFc not only homodimerizes but heterooligomerizes with ADSF\/resistin and prevents ADSF\/resistin inhibition of adipocyte differentiation of 3T3-L1 cells in a dominant negative manner. Transgenic mice overexpressing ADSF-hFc in adipose tissue show increased adiposity with elevated expression of adipocyte markers as well as enlarged adipocyte size. This finding clearly demonstrates\n                    <jats:italic>in vivo<\/jats:italic>\n                    the inhibitory role of ADSF in adipogenesis. ADSF-hFc transgenic mice with impaired ADSF function exhibit improved glucose tolerance and insulin sensitivity either on chow or high-fat diets. Because of the enhanced adipocyte differentiation, the ADSF-hFc transgenic mice show increased expression of leptin and adiponectin in adipose tissue. The elevated circulating levels for these adipocyte-derived hormones with decreased plasma triglyceride and free fatty acid levels may account for the improved glucose and insulin tolerance in these transgenic mice.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0305905101","type":"journal-article","created":{"date-parts":[[2004,4,16]],"date-time":"2004-04-16T20:43:11Z","timestamp":1082148191000},"page":"6780-6785","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":89,"title":["Dominant inhibitory adipocyte-specific secretory factor (ADSF)\/resistin enhances adipogenesis and improves insulin sensitivity"],"prefix":"10.1073","volume":"101","author":[{"given":"Kee-Hong","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Nutritional Sciences and Toxicology and Cancer Research Laboratory, Department of Molecular and Cell Biology, University of California, Berkeley, CA 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