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To study the role of Oct-1 in these processes, the lymphoid compartment of RAG-1\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    animals was reconstituted with Oct-1-deficient fetal liver hematopoietic cells. Recipient mice develop B cells with levels of surface Ig expression comparable with wild type, although at slightly reduced numbers. These B cells transcribe Ig normally, respond to antigenic stimulation, undergo class switching, and use a normal repertoire of light chain variable segments. However, recipient mice show slight reductions in serum IgM and IgA. Thus, the Oct-1 protein is dispensable for B cell development and Ig transcription.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0307304101","type":"journal-article","created":{"date-parts":[[2004,2,17]],"date-time":"2004-02-17T15:32:02Z","timestamp":1077031922000},"page":"2005-2010","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":33,"title":["B cell development and immunoglobulin transcription in Oct-1-deficient mice"],"prefix":"10.1073","volume":"101","author":[{"given":"Victoria E. 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