{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T02:25:39Z","timestamp":1792635939594,"version":"4.5.0"},"reference-count":42,"publisher":"National Academy of Sciences","issue":"11","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2004,3,16]]},"abstract":"<jats:p>\n                    The tumor necrosis factor (TNF) family member APRIL binds to the receptors BCMA on B cells and TACI on B and T cells. To investigate the role of APRIL in immunity, we generated APRIL-deficient mice. APRIL\n                    <jats:sup>-\/-<\/jats:sup>\n                    mice have normal T and B lymphocyte development, normal T and B cell proliferation\n                    <jats:italic>in vitro<\/jats:italic>\n                    , but increased numbers of CD44\n                    <jats:sup>hi<\/jats:sup>\n                    CD62L\n                    <jats:sup>lo<\/jats:sup>\n                    CD4\n                    <jats:sup>+<\/jats:sup>\n                    effector\/memory T cells and increased IgG responses to T-dependent antigens. Serum IgA levels were significantly decreased, and serum IgA antibody responses to mucosal immunization with TD antigens and to type 1 T-independent antigens were impaired in APRIL\n                    <jats:sup>-\/-<\/jats:sup>\n                    mice. APRIL by itself induced IgA as well as IgG1 isotype switching in CD40-deficient IgM\n                    <jats:sup>+<\/jats:sup>\n                    IgD\n                    <jats:sup>+<\/jats:sup>\n                    sorted B cells. These results suggest that APRIL down-regulates T cell-dependent antibody responses and promotes IgA class switching.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0307348101","type":"journal-article","created":{"date-parts":[[2004,3,16]],"date-time":"2004-03-16T12:57:51Z","timestamp":1079441871000},"page":"3903-3908","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":386,"title":["Impaired IgA class switching in APRIL-deficient mice"],"prefix":"10.1073","volume":"101","author":[{"given":"Emanuela","family":"Castigli","sequence":"first","affiliation":[{"name":"Division of Immunology, Children's Hospital and Department of Pediatrics, and Department of Pathology, Immunopathology Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumi","family":"Scott","sequence":"additional","affiliation":[{"name":"Division of Immunology, Children's Hospital and Department of Pediatrics, and Department of Pathology, Immunopathology Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma","family":"Dedeoglu","sequence":"additional","affiliation":[{"name":"Division of Immunology, Children's Hospital and Department of Pediatrics, and Department of Pathology, Immunopathology Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Bryce","sequence":"additional","affiliation":[{"name":"Division of Immunology, Children's Hospital and Department of Pediatrics, and Department of Pathology, Immunopathology Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifa","family":"Jabara","sequence":"additional","affiliation":[{"name":"Division of Immunology, Children's Hospital and Department of Pediatrics, and Department of Pathology, Immunopathology Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atul K.","family":"Bhan","sequence":"additional","affiliation":[{"name":"Division of Immunology, Children's Hospital and Department of Pediatrics, and Department of Pathology, Immunopathology Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emiko","family":"Mizoguchi","sequence":"additional","affiliation":[{"name":"Division of Immunology, Children's Hospital and Department of Pediatrics, and Department of Pathology, Immunopathology Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raif S.","family":"Geha","sequence":"additional","affiliation":[{"name":"Division of Immunology, Children's Hospital and Department of Pediatrics, and Department of Pathology, Immunopathology Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2004,2,26]]},"reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.21.120601.141152"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/embo-reports\/kve198"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.8.4314"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdf565"},{"key":"e_1_3_2_5_2","first-page":"1021","volume":"60","year":"2000","unstructured":"Kelly, K., Manos, E., Jensen, G., Nadauld, L. & Jones, D. 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