{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:37:44Z","timestamp":1791081464258,"version":"4.1.0"},"reference-count":40,"publisher":"National Academy of Sciences","issue":"6","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2004,2,10]]},"abstract":"<jats:p>\n                    A role for\n                    <jats:italic>Notch<\/jats:italic>\n                    in the elaboration of existing neural processes is emerging that is distinct from the increasingly well understood function of this gene in binary cell-fate decisions. Several research groups, by using a variety of organisms, have shown that\n                    <jats:italic>Notch<\/jats:italic>\n                    is important in the development of neural ultrastructure. Simultaneously,\n                    <jats:italic>Presenilin<\/jats:italic>\n                    (\n                    <jats:italic>Psn<\/jats:italic>\n                    ) was identified both as a key mediator of Notch signaling and as a site of genetic lesions that cause early-onset Alzheimer's disease. Here we demonstrate that\n                    <jats:italic>Notch<\/jats:italic>\n                    loss of function produces memory deficits in\n                    <jats:italic>Drosophila melanogaster<\/jats:italic>\n                    . The effects are specific to long-term memory, which is thought to depend on ultrastructural remodeling. We propose that Notch plays an important role in the neural plasticity underlying consolidated memory.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0308259100","type":"journal-article","created":{"date-parts":[[2004,2,10]],"date-time":"2004-02-10T13:32:51Z","timestamp":1076419971000},"page":"1764-1768","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":117,"title":["Notch is required for long-term memory in\n                    <i>Drosophila<\/i>"],"prefix":"10.1073","volume":"101","author":[{"given":"Asaf","family":"Presente","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, University of Nevada, 4505 Maryland Parkway, Las Vegas, NV 89154-4004"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randy S.","family":"Boyles","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Nevada, 4505 Maryland Parkway, Las Vegas, NV 89154-4004"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine N.","family":"Serway","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Nevada, 4505 Maryland Parkway, Las Vegas, NV 89154-4004"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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