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Additionally, we identified four amino acids (glutamate-101, isoleucine-103, leucine-112, and serine-115) critical for this activity. PEDF, or a derivative, could potentially abate or restore vision loss from diabetic macular edema. Furthermore, PEDF may represent a superior therapeutic approach to sepsis-associated hypotension, nephrotic syndrome, and other sight-threatening and life-threatening diseases resulting from excessive vascular permeability.<\/jats:p>","DOI":"10.1073\/pnas.0308342101","type":"journal-article","created":{"date-parts":[[2004,4,19]],"date-time":"2004-04-19T20:56:12Z","timestamp":1082408172000},"page":"6605-6610","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":103,"title":["Identification of the antivasopermeability effect of pigment epithelium-derived factor and its active site"],"prefix":"10.1073","volume":"101","author":[{"given":"Hua","family":"Liu","sequence":"first","affiliation":[{"name":"Wilmer Ophthalmological Institute, Johns Hopkins Hospital, Baltimore, MD 21287-8984; Transgenic Facility, Johns Hopkins University School of Medicine, Baltimore, MD 21205; and Krieger Children's Eye Center, Baltimore, MD 21287-9024"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Guo","family":"Ren","sequence":"additional","affiliation":[{"name":"Wilmer Ophthalmological Institute, Johns Hopkins Hospital, Baltimore, MD 21287-8984; Transgenic Facility, Johns Hopkins University School of Medicine, Baltimore, MD 21205; and Krieger Children's Eye Center, Baltimore, MD 21287-9024"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William L.","family":"Cooper","sequence":"additional","affiliation":[{"name":"Wilmer Ophthalmological Institute, Johns Hopkins Hospital, Baltimore, MD 21287-8984; Transgenic Facility, Johns Hopkins University School of Medicine, Baltimore, MD 21205; and Krieger Children's Eye Center, Baltimore, MD 21287-9024"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles E.","family":"Hawkins","sequence":"additional","affiliation":[{"name":"Wilmer Ophthalmological Institute, Johns Hopkins Hospital, Baltimore, MD 21287-8984; Transgenic Facility, Johns Hopkins University School of Medicine, Baltimore, MD 21205; and Krieger Children's Eye Center, Baltimore, MD 21287-9024"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitra R.","family":"Cowan","sequence":"additional","affiliation":[{"name":"Wilmer Ophthalmological Institute, Johns Hopkins Hospital, Baltimore, MD 21287-8984; Transgenic Facility, Johns Hopkins University School of Medicine, Baltimore, MD 21205; and Krieger Children's Eye Center, Baltimore, MD 21287-9024"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick Y.","family":"Tong","sequence":"additional","affiliation":[{"name":"Wilmer Ophthalmological Institute, Johns Hopkins Hospital, Baltimore, MD 21287-8984; Transgenic Facility, Johns Hopkins University School of Medicine, Baltimore, MD 21205; and Krieger Children's Eye Center, Baltimore, MD 21287-9024"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2004,4,19]]},"reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6823562"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114322"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2479987"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/88842"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-14-05731.1999"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-15-06401.2002"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)47116-5"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M002016200"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.43.31047"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.4.1526"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.43.25992"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M108896200"},{"key":"e_1_3_2_13_2","first-page":"1700","volume":"30","year":"1989","unstructured":"Tombran-Tink, J. & Johnson, L. 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