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Here, we investigated the function of phosphatase and tension homologue deleted on chromosome 10 (PTEN), a negative regulator of the phosphatidylinositol 3-kinase\/AKT pathway, by targeted deletion of\n                    <jats:italic>Pten<\/jats:italic>\n                    in murine liver. Deletion of\n                    <jats:italic>Pten<\/jats:italic>\n                    in the liver resulted in increased fatty acid synthesis, accompanied by hepatomegaly and fatty liver phenotype. Interestingly,\n                    <jats:italic>Pten<\/jats:italic>\n                    liver-specific deletion causes enhanced liver insulin action with improved systemic glucose tolerance. Thus, deletion of\n                    <jats:italic>Pten<\/jats:italic>\n                    in the liver may provide a valuable model that permits the study of the metabolic actions of insulin signaling in the liver, and PTEN may be a promising target for therapeutic intervention for type 2 diabetes.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0308617100","type":"journal-article","created":{"date-parts":[[2004,2,17]],"date-time":"2004-02-17T15:32:02Z","timestamp":1077031922000},"page":"2082-2087","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":401,"title":["Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity"],"prefix":"10.1073","volume":"101","author":[{"given":"Bangyan","family":"Stiles","sequence":"first","affiliation":[{"name":"Departments of Molecular and Medical Pharmacology and Howard Hughes Medical Institute and Department of Pediatrics Neonatology and Developmental Biology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095; Research Institute, Palo Alto Medical Foundation and Stanford School of Medicine, Palo Alto, CA 94301; Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA 90502; Department of Internal Medicine, Yale University School of Medicine, New Haven, CT..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"Departments of Molecular and Medical Pharmacology and Howard Hughes Medical Institute and Department of Pediatrics Neonatology and Developmental Biology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095; Research Institute, Palo Alto Medical Foundation and Stanford School of Medicine, Palo Alto, CA 94301; Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA 90502; Department of Internal Medicine, Yale University School of Medicine, New Haven, CT..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Stahl","sequence":"additional","affiliation":[{"name":"Departments of Molecular and Medical Pharmacology and Howard Hughes Medical Institute and Department of Pediatrics Neonatology and Developmental Biology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095; Research Institute, Palo Alto Medical Foundation and Stanford School of Medicine, Palo Alto, CA 94301; Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA 90502; Department of Internal Medicine, Yale University School of Medicine, New Haven, CT..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Bassilian","sequence":"additional","affiliation":[{"name":"Departments of Molecular and Medical Pharmacology and Howard Hughes Medical Institute and Department of Pediatrics Neonatology and Developmental Biology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095; Research Institute, Palo Alto Medical Foundation and Stanford School of Medicine, Palo Alto, CA 94301; Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA 90502; Department of Internal Medicine, Yale University School of Medicine, New Haven, CT..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Paul","family":"Lee","sequence":"additional","affiliation":[{"name":"Departments of Molecular and Medical Pharmacology and Howard Hughes Medical Institute and Department of Pediatrics Neonatology and Developmental Biology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095; Research Institute, Palo Alto Medical Foundation and Stanford School of Medicine, Palo Alto, CA 94301; Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA 90502; Department of Internal Medicine, Yale University School of Medicine, New Haven, CT..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon-Jung","family":"Kim","sequence":"additional","affiliation":[{"name":"Departments of Molecular and Medical Pharmacology and Howard Hughes Medical Institute and Department of Pediatrics Neonatology and Developmental Biology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095; Research Institute, Palo Alto Medical Foundation and Stanford School of Medicine, Palo Alto, CA 94301; 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Research Institute, Palo Alto Medical Foundation and Stanford School of Medicine, Palo Alto, CA 94301; Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA 90502; Department of Internal Medicine, Yale University School of Medicine, New Haven, CT..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Lesche","sequence":"additional","affiliation":[{"name":"Departments of Molecular and Medical Pharmacology and Howard Hughes Medical Institute and Department of Pediatrics Neonatology and Developmental Biology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095; Research Institute, Palo Alto Medical Foundation and Stanford School of Medicine, Palo Alto, CA 94301; Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA 90502; Department of Internal Medicine, Yale University School of Medicine, New Haven, CT..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Magnuson","sequence":"additional","affiliation":[{"name":"Departments of Molecular and Medical Pharmacology and Howard Hughes Medical Institute and Department of Pediatrics Neonatology and Developmental Biology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095; 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