{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T01:12:30Z","timestamp":1792717950077,"version":"4.5.0"},"reference-count":37,"publisher":"National Academy of Sciences","issue":"3","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2002,2,5]]},"abstract":"<jats:p>\n                    When males of the roundworm\n                    <jats:italic>Caenorhabditis elegans<\/jats:italic>\n                    come into association with their hermaphroditic counterparts they cease foraging behavior and begin to mate. Here we detail several assays used to demonstrate that a diffusible cue is correlated with this process. This cue is sexually dimorphic, given off only by the hermaphrodite and eliciting a response only in the male. Males are attracted to, reverse direction of movement frequently, and remain in regions of agar conditioned with hermaphrodites. From our studies we suggest a form of kinesis that works by attracting males to their mating partners from a distance and functions, once males arrive, in holding attracted males in close proximity. The hermaphrodite vulva is not required for the cue. Males from general sensory mutants\n                    <jats:italic>osm-5<\/jats:italic>\n                    and\n                    <jats:italic>osm-6<\/jats:italic>\n                    fail to respond to the cue, whereas male-specific mutants\n                    <jats:italic>lov-1<\/jats:italic>\n                    and\n                    <jats:italic>pkd-2<\/jats:italic>\n                    respond. Finally, that males from multiple isolates of\n                    <jats:italic>C. elegans<\/jats:italic>\n                    also respond similarly to this cue indicates that this cue is robust and has been maintained during recent evolution.\n                  <\/jats:p>","DOI":"10.1073\/pnas.032225799","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:36:44Z","timestamp":1027679804000},"page":"1598-1603","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":107,"title":["Evidence of a mate-finding cue in the hermaphrodite nematode\n                    <i>Caenorhabditis elegans<\/i>"],"prefix":"10.1073","volume":"99","author":[{"given":"Jasper M.","family":"Simon","sequence":"first","affiliation":[{"name":"Division of Biology and Howard Hughes Medical Institute, California Institute of Technology, Pasadena, CA 91125"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul W.","family":"Sternberg","sequence":"additional","affiliation":[{"name":"Division of Biology and Howard Hughes Medical Institute, California Institute of Technology, Pasadena, CA 91125"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2002,1,29]]},"reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01065444"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.en.18.010173.002025"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1159\/000114166"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(98)80032-9"},{"key":"e_1_3_2_5_2","first-page":"344","volume":"4","author":"Bronson F","year":"1971","unstructured":"F Bronson Biol Reprod 4, 344\u2013357 (1971).","journal-title":"Biol Reprod"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2749261"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1006\/hbeh.2000.1610"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)92890-5"},{"key":"e_1_3_2_9_2","first-page":"266","volume":"6","author":"Marchlewska-koj A","year":"1984","unstructured":"A Marchlewska-koj Oxford Rev Reprod Biol 6, 266\u2013302 (1984).","journal-title":"Oxford Rev Reprod Biol"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80698-4"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0083-6729(08)60075-8"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.106469"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00390-7"},{"key":"e_1_3_2_14_2","first-page":"327","volume":"49","author":"Green C","year":"1980","unstructured":"C Green Helminthol Abstr Ser B 49, 327\u2013339 (1980).","journal-title":"Helminthol Abstr Ser B"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-308X(08)60355-3"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.2307\/3276435"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.2307\/3278247"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000050861"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(95)90242-2"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0168-9525(87)90204-6"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(91)90004-E"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00305372"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/91.1.67"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/110.1.17"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/128.2.251"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(01)00423-7"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/146.1.149"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81609-8"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/103.1.43"},{"key":"e_1_3_2_30_2","first-page":"591","volume-title":"The Nematode Caenorhabditis elegans.","author":"Sulston J","year":"1988","unstructured":"J Sulston, J Hodgkin The Nematode Caenorhabditis elegans., ed W Wood (Cold Spring Harbor Lab. 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