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In the current study, a genome scan with 384 microsatellite markers was performed on 587 individuals in 60 multiplex pedigrees segregating PD and bladder\/kidney conditions. Using both single-locus and multipoint analytic methods, we found significant linkage on chromosome 22 (maximum heterogeneity logarithm of odds score = 4.11 at D22S445) and on chromosome 13q (heterogeneity logarithm of odds score = 3.57 at D13S793) under a dominant-genetic model and a broad phenotypic definition. Multipoint analyses did not support the observation on chromosome 22. The chromosome 13 findings were corroborated by multipoint findings, and extend our previous findings from 19 of the 60 families. Several other regions showed elevated scores by using when one analytic method was used, but not the other. These results suggest that there are genes on chromosome 13q, and possibly on chromosome 22 as well, that influence the susceptibility toward a pleiotropic syndrome that includes PD, bladder problems, severe headaches, mitral valve prolapse, and thyroid conditions.<\/jats:p>","DOI":"10.1073\/pnas.0335669100","type":"journal-article","created":{"date-parts":[[2003,3,4]],"date-time":"2003-03-04T13:36:00Z","timestamp":1046784960000},"page":"2550-2555","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":100,"title":["Further genetic evidence for a panic disorder syndrome mapping to chromosome 13q"],"prefix":"10.1073","volume":"100","author":[{"given":"Steven P.","family":"Hamilton","sequence":"first","affiliation":[{"name":"Department of Psychiatry, College of Physicians and Surgeons at Columbia University and the New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032; Columbia Genome Center, College of Physicians and Surgeons at Columbia University, 1051 Riverside Drive, New York, NY 10032; 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