{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:08:47Z","timestamp":1791414527147,"version":"4.3.3"},"reference-count":58,"publisher":"National Academy of Sciences","issue":"15","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2004,4,13]]},"abstract":"<jats:p>\n                    Both\n                    <jats:italic>all-trans<\/jats:italic>\n                    retinoic acid (ATRA) and arsenic trioxide (As\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>3<\/jats:sub>\n                    ) have proven to be very effective in obtaining high clinical complete remission (CR) rates in acute promyelocytic leukemia (APL), but they had not been used jointly in an integrated treatment protocol for remission induction or maintenance among newly diagnosed APL patients. In this study, 61 newly diagnosed APL subjects were randomized into three treatment groups, namely by ATRA, As\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>3<\/jats:sub>\n                    , and the combination of the two drugs. CR was determined by hematological analysis, tumor burden was examined with real-time quantitative RT-PCR of the\n                    <jats:italic>PML-RAR<\/jats:italic>\n                    \u03b1 (promyelocytic leukemia\n                    <jats:italic>-<\/jats:italic>\n                    retinoic acid receptor \u03b1) fusion transcripts, and side effects were evaluated by means of clinical examinations. Mechanisms possibly involved were also investigated with cellular and molecular biology methods. Although CR rates in three groups were all high (\u226590%), the time to achieve CR differed significantly, with that of the combination group being the shortest one. Earlier recovery of platelet count was also found in this group. The disease burden as reflected by fold change of PML-RAR\u03b1 transcripts at CR decreased more significantly in combined therapy as compared with ATRA or As\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>3<\/jats:sub>\n                    mono-therapy (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.01). This difference persisted after consolidation (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.05). Importantly, all 20 cases in the combination group remained in CR whereas 7 of 37 cases treated with mono-therapy relapsed (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.05) after a follow-up of 8\u201330 months (median: 18 months). Synergism of ATRA and As\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>3<\/jats:sub>\n                    on apoptosis and degradation of PML-RAR\u03b1 oncoprotein might provide a plausible explanation for superior efficacy of combinative therapy in clinic. In conclusion, the ATRA\/As\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>3<\/jats:sub>\n                    combination for remission\/maintenance therapy of APL brings much better results than either of the two drugs used alone in terms of the quality of CR and the status of the disease-free survival.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0400053101","type":"journal-article","created":{"date-parts":[[2004,3,25]],"date-time":"2004-03-25T08:18:00Z","timestamp":1080202680000},"page":"5328-5335","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":514,"title":["<i>All-trans<\/i>\n                    retinoic acid\/As\n                    <sub>2<\/sub>\n                    O\n                    <sub>3<\/sub>\n                    combination yields a high quality remission and survival in newly diagnosed acute promyelocytic leukemia"],"prefix":"10.1073","volume":"101","author":[{"given":"Zhi-Xiang","family":"Shen","sequence":"first","affiliation":[{"name":"Shanghai Institute of Hematology, State Key Lab of Medical Genomics, Rui Jin Hospital affiliated with Shanghai Second Medical University, 197 Rui Jin Road II, Shanghai 200025, China; Centre National de la Recherche Scientifique, Unit\u00e9 Propre de Recherche 9051, Laboratoire Associ\u00e9 du Comit\u00e9 de Paris de la Ligue Contre le Cancer, Affili\u00e9 \u00e0 l'Universit\u00e9 de Paris VII, H\u00f4pital St. Louis, 1 Avenue C. Vellefaux, 75475 Paris Cedex 10, France; and Division of Neoplastic Diseases, Department of Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhan-Zhong","family":"Shi","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Hematology, State Key Lab of Medical Genomics, Rui Jin Hospital affiliated with Shanghai Second Medical University, 197 Rui Jin Road II, Shanghai 200025, China; Centre National de la Recherche Scientifique, Unit\u00e9 Propre de Recherche 9051, Laboratoire Associ\u00e9 du Comit\u00e9 de Paris de la Ligue Contre le Cancer, Affili\u00e9 \u00e0 l'Universit\u00e9 de Paris VII, H\u00f4pital St. Louis, 1 Avenue C. Vellefaux, 75475 Paris Cedex 10, France; and Division of Neoplastic Diseases, Department of Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Fang","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Hematology, State Key Lab of Medical Genomics, Rui Jin Hospital affiliated with Shanghai Second Medical University, 197 Rui Jin Road II, Shanghai 200025, China; Centre National de la Recherche Scientifique, Unit\u00e9 Propre de Recherche 9051, Laboratoire Associ\u00e9 du Comit\u00e9 de Paris de la Ligue Contre le Cancer, Affili\u00e9 \u00e0 l'Universit\u00e9 de Paris VII, H\u00f4pital St. Louis, 1 Avenue C. Vellefaux, 75475 Paris Cedex 10, France; and Division of Neoplastic Diseases, Department of Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bai-Wei","family":"Gu","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Hematology, State Key Lab of Medical Genomics, Rui Jin Hospital affiliated with Shanghai Second Medical University, 197 Rui Jin Road II, Shanghai 200025, China; Centre National de la Recherche Scientifique, Unit\u00e9 Propre de Recherche 9051, Laboratoire Associ\u00e9 du Comit\u00e9 de Paris de la Ligue Contre le Cancer, Affili\u00e9 \u00e0 l'Universit\u00e9 de Paris VII, H\u00f4pital St. Louis, 1 Avenue C. Vellefaux, 75475 Paris Cedex 10, France; and Division of Neoplastic Diseases, Department of Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Min","family":"Li","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Hematology, State Key Lab of Medical Genomics, Rui Jin Hospital affiliated with Shanghai Second Medical University, 197 Rui Jin Road II, Shanghai 200025, China; Centre National de la Recherche Scientifique, Unit\u00e9 Propre de Recherche 9051, Laboratoire Associ\u00e9 du Comit\u00e9 de Paris de la Ligue Contre le Cancer, Affili\u00e9 \u00e0 l'Universit\u00e9 de Paris VII, H\u00f4pital St. Louis, 1 Avenue C. Vellefaux, 75475 Paris Cedex 10, France; and Division of Neoplastic Diseases, Department of Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Mei","family":"Zhu","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Hematology, State Key Lab of Medical Genomics, Rui Jin Hospital affiliated with Shanghai Second Medical University, 197 Rui Jin Road II, Shanghai 200025, China; Centre National de la Recherche Scientifique, Unit\u00e9 Propre de Recherche 9051, Laboratoire Associ\u00e9 du Comit\u00e9 de Paris de la Ligue Contre le Cancer, Affili\u00e9 \u00e0 l'Universit\u00e9 de Paris VII, H\u00f4pital St. Louis, 1 Avenue C. Vellefaux, 75475 Paris Cedex 10, France; and Division of Neoplastic Diseases, Department of Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Yi","family":"Shi","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Hematology, State Key Lab of Medical Genomics, Rui Jin Hospital affiliated with Shanghai Second Medical University, 197 Rui Jin Road II, Shanghai 200025, China; Centre National de la Recherche Scientifique, Unit\u00e9 Propre de Recherche 9051, Laboratoire Associ\u00e9 du Comit\u00e9 de Paris de la Ligue Contre le Cancer, Affili\u00e9 \u00e0 l'Universit\u00e9 de Paris VII, H\u00f4pital St. Louis, 1 Avenue C. Vellefaux, 75475 Paris Cedex 10, France; and Division of Neoplastic Diseases, Department of Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Zheng","family":"Zheng","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Hematology, State Key Lab of Medical Genomics, Rui Jin Hospital affiliated with Shanghai Second Medical University, 197 Rui Jin Road II, Shanghai 200025, China; Centre National de la Recherche Scientifique, Unit\u00e9 Propre de Recherche 9051, Laboratoire Associ\u00e9 du Comit\u00e9 de Paris de la Ligue Contre le Cancer, Affili\u00e9 \u00e0 l'Universit\u00e9 de Paris VII, H\u00f4pital St. Louis, 1 Avenue C. Vellefaux, 75475 Paris Cedex 10, France; and Division of Neoplastic Diseases, Department of Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Yan","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Hematology, State Key Lab of Medical Genomics, Rui Jin Hospital affiliated with Shanghai Second Medical University, 197 Rui Jin Road II, Shanghai 200025, China; Centre National de la Recherche Scientifique, Unit\u00e9 Propre de Recherche 9051, Laboratoire Associ\u00e9 du Comit\u00e9 de Paris de la Ligue Contre le Cancer, Affili\u00e9 \u00e0 l'Universit\u00e9 de Paris VII, H\u00f4pital St. Louis, 1 Avenue C. Vellefaux, 75475 Paris Cedex 10, France; and Division of Neoplastic Diseases, Department of Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Fang","family":"Liu","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Hematology, State Key Lab of Medical Genomics, Rui Jin Hospital affiliated with Shanghai Second Medical University, 197 Rui Jin Road II, Shanghai 200025, China; Centre National de la Recherche Scientifique, Unit\u00e9 Propre de Recherche 9051, Laboratoire Associ\u00e9 du Comit\u00e9 de Paris de la Ligue Contre le Cancer, Affili\u00e9 \u00e0 l'Universit\u00e9 de Paris VII, H\u00f4pital St. Louis, 1 Avenue C. Vellefaux, 75475 Paris Cedex 10, France; and Division of Neoplastic Diseases, Department of Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Hematology, State Key Lab of Medical Genomics, Rui Jin Hospital affiliated with Shanghai Second Medical University, 197 Rui Jin Road II, Shanghai 200025, China; Centre National de la Recherche Scientifique, Unit\u00e9 Propre de Recherche 9051, Laboratoire Associ\u00e9 du Comit\u00e9 de Paris de la Ligue Contre le Cancer, Affili\u00e9 \u00e0 l'Universit\u00e9 de Paris VII, H\u00f4pital St. Louis, 1 Avenue C. Vellefaux, 75475 Paris Cedex 10, France; and Division of Neoplastic Diseases, Department of Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Shen","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Hematology, State Key Lab of Medical Genomics, Rui Jin Hospital affiliated with Shanghai Second Medical University, 197 Rui Jin Road II, Shanghai 200025, China; Centre National de la Recherche Scientifique, Unit\u00e9 Propre de Recherche 9051, Laboratoire Associ\u00e9 du Comit\u00e9 de Paris de la Ligue Contre le Cancer, Affili\u00e9 \u00e0 l'Universit\u00e9 de Paris VII, H\u00f4pital St. Louis, 1 Avenue C. Vellefaux, 75475 Paris Cedex 10, France; and Division of Neoplastic Diseases, Department of Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Wu","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Hematology, State Key Lab of Medical Genomics, Rui Jin Hospital affiliated with Shanghai Second Medical University, 197 Rui Jin Road II, Shanghai 200025, China; Centre National de la Recherche Scientifique, Unit\u00e9 Propre de Recherche 9051, Laboratoire Associ\u00e9 du Comit\u00e9 de Paris de la Ligue Contre le Cancer, Affili\u00e9 \u00e0 l'Universit\u00e9 de Paris VII, H\u00f4pital St. Louis, 1 Avenue C. Vellefaux, 75475 Paris Cedex 10, France; and Division of Neoplastic Diseases, Department of Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Tang","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Hematology, State Key Lab of Medical Genomics, Rui Jin Hospital affiliated with Shanghai Second Medical University, 197 Rui Jin Road II, Shanghai 200025, China; Centre National de la Recherche Scientifique, Unit\u00e9 Propre de Recherche 9051, Laboratoire Associ\u00e9 du Comit\u00e9 de Paris de la Ligue Contre le Cancer, Affili\u00e9 \u00e0 l'Universit\u00e9 de Paris VII, H\u00f4pital St. Louis, 1 Avenue C. Vellefaux, 75475 Paris Cedex 10, France; and Division of Neoplastic Diseases, Department of Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Waxman","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Hematology, State Key Lab of Medical Genomics, Rui Jin Hospital affiliated with Shanghai Second Medical University, 197 Rui Jin Road II, Shanghai 200025, China; Centre National de la Recherche Scientifique, Unit\u00e9 Propre de Recherche 9051, Laboratoire Associ\u00e9 du Comit\u00e9 de Paris de la Ligue Contre le Cancer, Affili\u00e9 \u00e0 l'Universit\u00e9 de Paris VII, H\u00f4pital St. Louis, 1 Avenue C. Vellefaux, 75475 Paris Cedex 10, France; and Division of Neoplastic Diseases, Department of Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugues","family":"de Th\u00e9","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Hematology, State Key Lab of Medical Genomics, Rui Jin Hospital affiliated with Shanghai Second Medical University, 197 Rui Jin Road II, Shanghai 200025, China; Centre National de la Recherche Scientifique, Unit\u00e9 Propre de Recherche 9051, Laboratoire Associ\u00e9 du Comit\u00e9 de Paris de la Ligue Contre le Cancer, Affili\u00e9 \u00e0 l'Universit\u00e9 de Paris VII, H\u00f4pital St. Louis, 1 Avenue C. Vellefaux, 75475 Paris Cedex 10, France; and Division of Neoplastic Diseases, Department of Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Hematology, State Key Lab of Medical Genomics, Rui Jin Hospital affiliated with Shanghai Second Medical University, 197 Rui Jin Road II, Shanghai 200025, China; Centre National de la Recherche Scientifique, Unit\u00e9 Propre de Recherche 9051, Laboratoire Associ\u00e9 du Comit\u00e9 de Paris de la Ligue Contre le Cancer, Affili\u00e9 \u00e0 l'Universit\u00e9 de Paris VII, H\u00f4pital St. Louis, 1 Avenue C. Vellefaux, 75475 Paris Cedex 10, France; and Division of Neoplastic Diseases, Department of Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sai-Juan","family":"Chen","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Hematology, State Key Lab of Medical Genomics, Rui Jin Hospital affiliated with Shanghai Second Medical University, 197 Rui Jin Road II, Shanghai 200025, China; Centre National de la Recherche Scientifique, Unit\u00e9 Propre de Recherche 9051, Laboratoire Associ\u00e9 du Comit\u00e9 de Paris de la Ligue Contre le Cancer, Affili\u00e9 \u00e0 l'Universit\u00e9 de Paris VII, H\u00f4pital St. Louis, 1 Avenue C. Vellefaux, 75475 Paris Cedex 10, France; and Division of Neoplastic Diseases, Department of Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhu","family":"Chen","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Hematology, State Key Lab of Medical Genomics, Rui Jin Hospital affiliated with Shanghai Second Medical University, 197 Rui Jin Road II, Shanghai 200025, China; Centre National de la Recherche Scientifique, Unit\u00e9 Propre de Recherche 9051, Laboratoire Associ\u00e9 du Comit\u00e9 de Paris de la Ligue Contre le Cancer, Affili\u00e9 \u00e0 l'Universit\u00e9 de Paris VII, H\u00f4pital St. Louis, 1 Avenue C. Vellefaux, 75475 Paris Cedex 10, France; and Division of Neoplastic Diseases, Department of Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2004,3,24]]},"reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.6.2551"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-02-0352"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.67.3.1542"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V57.6.1000.1000"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V72.2.567.567"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V76.9.1704.1704"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199105163242002"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401859"},{"key":"e_1_3_2_9_2","first-page":"963","volume":"112","year":"1999","unstructured":"Wang, Z. Y., Sun, G. L., Shen, Z .X., Chen, S. J. & Chen, Z. (1999) Chin. Med. J. 112, 963\u2013967.11721474","journal-title":"Chin. Med. J."},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-02-0632"},{"key":"e_1_3_2_11_2","first-page":"248","volume":"70","year":"1999","unstructured":"Hu, J., Shen, Z. X., Sun, G. L., Chen, S. J., Wang, Z. Y. & Chen, Z. (1999) Int. J. Hematol. 70, 248\u2013260.10643151","journal-title":"Int. J. Hematol."},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.9.3354"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199811053391901"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V94.10.3315.422k16_3315_3324"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402106"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11314"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/90.2.124"},{"key":"e_1_3_2_18_2","first-page":"1103","volume":"111","year":"2000","unstructured":"Kennedy, G. A., Marlton, P., Cobcroft, R. & Gill, D. (2000) Br. J. Haematol. 111, 1103\u20131105.11167746","journal-title":"Br. J. Haematol."},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.189.7.1043"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.1.264"},{"key":"e_1_3_2_21_2","first-page":"ELT15","volume":"88","year":"2003","unstructured":"Visani, G., Piccaluga, P. P., Martinelli, G., Rossi, M., Malagola, M. & Baccarani, M. (2003) Haematologica 88, ELT15.12681992","journal-title":"Haematologica"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2002.03409.x"},{"key":"e_1_3_2_23_2","first-page":"32","volume":"24","year":"2003","unstructured":"Zhao, Y. Z., Li, H. Q., Li, D. P., Li, R., Qi, J. Y., Wan, C. C., Zhou, C. L., Wang, Z. Q. & Qian, L. S. (2003) Chin. J. Hematol. 24, 32\u201334.","journal-title":"Chin. J. Hematol."},{"key":"e_1_3_2_24_2","first-page":"2945","volume":"56","year":"1996","unstructured":"Yoshida, H., Kitamura, K., Tanaka, K., Omura, S., Miyazaki, T., Hachiya, T., Ohno, R. Y Naoe, T. (1996) Cancer Res. 56, 2945\u20132948.8674046","journal-title":"Cancer Res."},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.8.2826.bloodjournal8882826"},{"key":"e_1_3_2_26_2","first-page":"2244","volume":"92","year":"1998","unstructured":"Nervi, C., Ferrara, F. F., Fanelli, M., Rippo, M. R., Tomassini, B., Ferrucci, P. F., Ruthardt, M., Gelmetti, V., Gambacorti-Passerini, C., Diverio, D., et al. (1998) Blood 92, 2244\u20132251.9746761","journal-title":"Blood"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.8.3978"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.26.14807"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204852"},{"key":"e_1_3_2_30_2","unstructured":"Jaffe E. S. Harris N. L. Stein H. & Vardiman J. W. eds. (2001) Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues (IARC Press Lyon) pp. 75\u2013107."},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199710093371501"},{"key":"e_1_3_2_32_2","first-page":"825","volume":"10","year":"1996","unstructured":"Chen, G. Q., Shen, Z. X., Wu, F., Han, J. Y., Miao, J. M., Zhong, H. J., Li, X. S., Zhao, J. Q., Zhu, J., Fang, Z. W., et al. (1996) Leukemia 10, 825\u2013828.8656678","journal-title":"Leukemia"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19810101)47:1<207::AID-CNCR2820470134>3.0.CO;2-6"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1159\/000130909"},{"key":"e_1_3_2_35_2","unstructured":"ISCN (1995) Guidelines for Cancer Cytogenetics (Karger Basel)."},{"key":"e_1_3_2_36_2","first-page":"302","volume":"9","year":"1995","unstructured":"Zhu, J., Shi, X. G., Chu, H. Y., Tong, J. H., Wang, Z. Y., Naoe, T., Waxman, S., Chen, S. J. & Chen, Z. (1995) Leukemia 9, 302\u2013309.7869768","journal-title":"Leukemia"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.thj.6200128"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.5.1701"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc887"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.308"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196512092732403"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.01.149"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401448"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V82.4.1264.1264"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-05-1357"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-03-0880"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V91.11.4300"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207205"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206747"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/35895"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/35901"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.279.5356.1547"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.11.6318"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.3.1014"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403226"},{"key":"e_1_3_2_56_2","unstructured":"Chen Z. & Wang Z. Y. (2003) in Treatment of Acute Leukemias: New Directions for Clinical Research Current Clinical Oncology ed. Pui C.-H. (Humana Totowa NJ) pp. 291\u2013308."},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.193.12.1361"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1053\/shem.2002.33611"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.0400053101","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T21:59:00Z","timestamp":1650923940000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.0400053101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,3,24]]},"references-count":58,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2004,4,13]]}},"alternative-id":["10.1073\/pnas.0400053101"],"URL":"https:\/\/doi.org\/10.1073\/pnas.0400053101","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,3,24]]},"assertion":[{"value":"2004-03-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}