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The majority of ARJP-associated parkin mutations are thought to be loss of function-mutations; however, the pathogenesis of ARJP remains poorly understood. Here, we report the generation of parkin null mice by targeted deletion of parkin exon 7. These mice show a loss of catecholaminergic neurons in the locus coeruleus and an accompanying loss of norepinephrine in discrete regions of the central nervous system. Moreover, there is a dramatic reduction of the norepinephrine-dependent startle response. The nigrostriatal dopaminergic system does not show any impairment. This mouse model will help gain a better understanding of parkin function and the mechanisms underlying parkin-associated PD.<\/jats:p>","DOI":"10.1073\/pnas.0401297101","type":"journal-article","created":{"date-parts":[[2004,7,12]],"date-time":"2004-07-12T20:20:45Z","timestamp":1089663645000},"page":"10744-10749","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":304,"title":["Loss of locus coeruleus neurons and reduced startle in parkin null mice"],"prefix":"10.1073","volume":"101","author":[{"given":"Rainer","family":"von Coelln","sequence":"first","affiliation":[{"name":"Institute for Cell Engineering, and Departments of Neurology, Neuroscience, and Physiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bobby","family":"Thomas","sequence":"additional","affiliation":[{"name":"Institute for Cell Engineering, and Departments of Neurology, 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