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The S-isomers of FLX and NFLX are 2- and 7-fold more potent, respectively, than their respective R-isomers. The EC\n                    <jats:sub>50<\/jats:sub>\n                    s of FLX and NFLX required to normalize brain Allo content and PTB action are 10\u201350 times lower than the IC\n                    <jats:sub>50<\/jats:sub>\n                    s required for selective serotonin reuptake inhibitor activity. We conclude that normalization of PTB action elicited by the S-isomers of FLX and NFLX is related to the reversal of the down-regulation of brain Allo content and is independent of selective serotonin reuptake inhibitor activity.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0401479101","type":"journal-article","created":{"date-parts":[[2004,4,6]],"date-time":"2004-04-06T22:12:53Z","timestamp":1081289573000},"page":"6222-6225","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":58,"title":["Fluoxetine and norfluoxetine stereospecifically facilitate pentobarbital sedation by increasing neurosteroids"],"prefix":"10.1073","volume":"101","author":[{"given":"Graziano","family":"Pinna","sequence":"first","affiliation":[{"name":"Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois, Chicago, IL 60612"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erminio","family":"Costa","sequence":"additional","affiliation":[{"name":"Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois, Chicago, IL 60612"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Guidotti","sequence":"additional","affiliation":[{"name":"Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois, Chicago, IL 60612"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2004,4,6]]},"reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(99)00018-0"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(01)00129-1"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0337642100"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(99)00149-5"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.051628598"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(90)90202-Q"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(02)00172-7"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2003.09.001"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1999.0513v.x"},{"key":"e_1_3_2_10_2","first-page":"49","volume":"44","year":"2002","unstructured":"Puia, G., Mienville, J.-M., Matsumoto, K., Takahata, H., Watanabe, H., Costa, E. & Guidotti, A. 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