{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:32:54Z","timestamp":1791419574179,"version":"4.3.3"},"reference-count":29,"publisher":"National Academy of Sciences","issue":"22","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2004,6]]},"abstract":"<jats:p>\n                    The astrocyte represents the most abundant yet least understood cell type of the CNS. Here, we use a stringent experimental strategy to molecularly define the astrocyte lineage by integrating microarray datasets across several\n                    <jats:italic>in vitro<\/jats:italic>\n                    model systems of astrocyte differentiation, primary astrocyte cultures, and various astrocyterich CNS structures. The intersection of astrocyte data sets, coupled with the application of nonastrocytic exclusion filters, yielded many astrocyte-specific genes possessing strikingly varied patterns of regional CNS expression. Annotation of these astrocyte-specific genes provides direct molecular documentation of the diverse physiological roles of the astrocyte lineage. This global perspective in the normal brain also provides a framework for how astrocytes may participate in the pathogenesis of common neurological disorders like Alzheimer's disease, Parkinson's disease, stroke, epilepsy, and primary brain tumors.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0402140101","type":"journal-article","created":{"date-parts":[[2004,5,21]],"date-time":"2004-05-21T21:05:34Z","timestamp":1085173534000},"page":"8384-8389","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":191,"title":["Molecular diversity of astrocytes with implications for neurological disorders"],"prefix":"10.1073","volume":"101","author":[{"given":"Robert M.","family":"Bachoo","sequence":"first","affiliation":[{"name":"Departments of Medical Oncology and Pediatric Oncology, Dana\u2013Farber Cancer Institute, 44 Binney Street, Boston, MA 02115; Department of Neurology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115; Departments of Biostatistics and Statistics, Harvard University, Boston, MA 02115; Departments of Medicine and Genetics, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryung S.","family":"Kim","sequence":"additional","affiliation":[{"name":"Departments of Medical Oncology and Pediatric Oncology, Dana\u2013Farber Cancer Institute, 44 Binney Street, Boston, MA 02115; Department of Neurology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115; Departments of Biostatistics and Statistics, Harvard University, Boston, MA 02115; Departments of Medicine and Genetics, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith L.","family":"Ligon","sequence":"additional","affiliation":[{"name":"Departments of Medical Oncology and Pediatric Oncology, Dana\u2013Farber Cancer Institute, 44 Binney Street, Boston, MA 02115; Department of Neurology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115; 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