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In this study, we provide functional evidence for the contribution of API2\/MALT1 fusion proteins to transformation of cells in culture by activating the NF-\u03baB pathway through a RelB\/p50 dimer. Using microchip gene expression analysis, we demonstrate that different forms of the API2\/MALT1 proteins activate both unique and overlapping gene programs in cells. In addition to this genome reprogramming, expression of distinct API2\/MALT1 fusion products inhibits DNA damage-induced, p53-mediated apoptosis in an NF-\u03baB-dependent manner. Collectively, these data reveal previously unknown functional diversity among API2\/MALT1 fusion products and their function in NF-\u03baB signaling as it connects to the apoptotic program, a pathway with strong relevance to cancer. Furthermore, they provide evidence underlying the emerging role of the NF-\u03baB signaling pathway in the inhibition of apoptosis.<\/jats:p>","DOI":"10.1073\/pnas.0402415101","type":"journal-article","created":{"date-parts":[[2004,6,7]],"date-time":"2004-06-07T21:09:33Z","timestamp":1086642573000},"page":"9079-9084","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":52,"title":["Activation of NF-\u03baB and inhibition of p53-mediated apoptosis by API2\/mucosa-associated lymphoid tissue 1 fusions promote oncogenesis"],"prefix":"10.1073","volume":"101","author":[{"given":"Archontoula","family":"Stoffel","sequence":"first","affiliation":[{"name":"Laboratory for Cancer Biology, The Rockefeller University, 1230 York Avenue, Box 290, New York, NY 10021; Laborarory for Epithelial Cancer Biology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021; and Institute for Advanced Study, Einstein Drive, Princeton, NJ 08540"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mira","family":"Chaurushiya","sequence":"additional","affiliation":[{"name":"Laboratory for Cancer Biology, The Rockefeller University, 1230 York Avenue, Box 290, New York, NY 10021; Laborarory for Epithelial Cancer Biology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021; and Institute for Advanced Study, Einstein Drive, Princeton, NJ 08540"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhuvanesh","family":"Singh","sequence":"additional","affiliation":[{"name":"Laboratory for Cancer Biology, The Rockefeller University, 1230 York Avenue, Box 290, New York, NY 10021; Laborarory for Epithelial Cancer Biology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021; and Institute for Advanced Study, Einstein Drive, Princeton, NJ 08540"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnold J.","family":"Levine","sequence":"additional","affiliation":[{"name":"Laboratory for Cancer Biology, The Rockefeller University, 1230 York Avenue, Box 290, New York, NY 10021; Laborarory for Epithelial Cancer Biology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021; and Institute for Advanced Study, Einstein Drive, Princeton, NJ 08540"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2004,6,7]]},"reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1998.00513.x"},{"key":"e_1_3_2_2_2","first-page":"3944","volume":"57","year":"1997","unstructured":"Ott, G., Katzenberger, D. 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