{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:28:41Z","timestamp":1791232121832,"version":"4.1.0"},"reference-count":29,"publisher":"National Academy of Sciences","issue":"39","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2004,9,28]]},"abstract":"<jats:p>\n                    The complete genome sequence of\n                    <jats:italic>Burkholderia mallei<\/jats:italic>\n                    ATCC 23344 provides insight into this highly infectious bacterium's pathogenicity and evolutionary history.\n                    <jats:italic>B. mallei<\/jats:italic>\n                    , the etiologic agent of glanders, has come under renewed scientific investigation as a result of recent concerns about its past and potential future use as a biological weapon. Genome analysis identified a number of putative virulence factors whose function was supported by comparative genome hybridization and expression profiling of the bacterium in hamster liver\n                    <jats:italic>in vivo<\/jats:italic>\n                    . The genome contains numerous insertion sequence elements that have mediated extensive deletions and rearrangements of the genome relative to\n                    <jats:italic>Burkholderia pseudomallei<\/jats:italic>\n                    . The genome also contains a vast number (&gt;12,000) of simple sequence repeats. Variation in simple sequence repeats in key genes can provide a mechanism for generating antigenic variation that may account for the mammalian host's inability to mount a durable adaptive immune response to a\n                    <jats:italic>B. mallei<\/jats:italic>\n                    infection.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0403306101","type":"journal-article","created":{"date-parts":[[2004,9,17]],"date-time":"2004-09-17T20:29:25Z","timestamp":1095452965000},"page":"14246-14251","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":328,"title":["Structural flexibility in the\n                    <i>Burkholderia mallei<\/i>\n                    genome"],"prefix":"10.1073","volume":"101","author":[{"given":"William C.","family":"Nierman","sequence":"first","affiliation":[{"name":"Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Departments of Biochemistry and Molecular Biology, Pharmacology, and Microbiology and Tropical Medicine, George Washington University School of Medicine, 2300 Eye Street NW, Washington, DC 20037; and U.S. Army Medical Research Institute for Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702-5011"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"DeShazer","sequence":"additional","affiliation":[{"name":"Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Departments of Biochemistry and Molecular Biology, Pharmacology, and Microbiology and Tropical Medicine, George Washington University School of Medicine, 2300 Eye Street NW, Washington, DC 20037; and U.S. Army Medical Research Institute for Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702-5011"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. 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