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Further investigation revealed that vascular endothelial growth factor-C and -D are required for this apparent lymphangiogenic property of FGF-2, and when the small amount of accompanying angiogenesis was completely suppressed, lymphangiogenesis remained unaffected. Our findings demonstrate that there is a dose-dependent response of FGF-2 for lymphangiogenesis, and lymphangiogenesis can occur in the absence of a preexisting or developing vascular bed, i.e., in the absence of angiogenesis, in the mouse cornea.<\/jats:p>","DOI":"10.1073\/pnas.0404272101","type":"journal-article","created":{"date-parts":[[2004,8,2]],"date-time":"2004-08-02T20:15:35Z","timestamp":1091477735000},"page":"11658-11663","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":231,"title":["Dose-dependent response of FGF-2 for lymphangiogenesis"],"prefix":"10.1073","volume":"101","author":[{"given":"Lynn K.","family":"Chang","sequence":"first","affiliation":[{"name":"Vascular Biology Program, Department of Surgery, Children's Hospital Boston, Center for Excellence in Vascular Biology, Department of Pathology, Brigham and Women's Hospital, and Department of Genetics, Division of Molecular Medicine, Harvard Medical School, 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