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Here we demonstrate nAb-mediated viral clearance in CTL-deficient mice infected with the prototypic noncytopathic lymphocytic choriomeningitis virus (strain WE). During prolonged CTL absence, neutralization-resistant virus mutants were selected in individual mice within 70\u201390 days. In na\u00efve animals infected with these virus variants only low nAb responses were induced, resulting in an increased tendency of virus to persist.\n                  <\/jats:p>","DOI":"10.1073\/pnas.040558797","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:38:21Z","timestamp":1027679901000},"page":"2749-2754","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":120,"title":["Viral persistence\n                    <i>in vivo<\/i>\n                    through selection of neutralizing antibody-escape variants"],"prefix":"10.1073","volume":"97","author":[{"given":"Adrian","family":"Ciurea","sequence":"first","affiliation":[{"name":"Institute for Experimental Immunology, University Hospital, CH-8091 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Klenerman","sequence":"additional","affiliation":[{"name":"Institute for Experimental Immunology, 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